The Association Between Systemic Microvascular Endothelial Function &

Status Completed

Clinical Trial Summary

The present study evaluates skin microvascular reactivity and coronary physiology in the same coronary artery disease (CAD) patients. This study is expected to find associations between systemic microvascular reactivity, measured non-invasively at the skin surface, and coronary reserve evaluated by the invasive angiographic method.

Clinical Trial Description

Introduction: Microvascular reactivity (MR) evaluated in the skin has been proposed as representative of systemic endothelial function, including coronary circulation. There is a lack of studies investigating the association between skin MR and invasive evaluation of coronary reserve. Objective: To evaluate skin MR and coronary physiology in the same coronary artery disease (CAD) patients. Methods: Transversal study, recruiting adult patients with indication for elective coronary angiographic study for the evaluation of CAD by an independent medical team. The evaluation of microvascular cutaneous blood flow of the forearm will use laser speckle contrast imaging (LSCI) coupled with acetylcholine iontophoresis. Coronary physiology will be evaluated in the same patients and in the same day with coronary angiography with lesion assessment by fractional flow reserve (FFR, after intracoronary adenosine administration) and contrast fractional flow reserve (cFFR, after intracoronary contrast media administration), with measurements of hyperemic intravascular pressures. FFR and cFFR will be performed in vessels with intermediate lesions, as evaluated in quantitative angiography. Expected results: This study is expected to find associations between systemic MR, measured non-invasively at the skin surface, and coronary reserve evaluated by the invasive angiographic method. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05864729
Study type	Interventional
Source	National Institute of Cardiology, Laranjeiras, Brazil
Contact
Status	Completed
Phase	N/A
Start date	June 1, 2021
Completion date	December 1, 2023

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT06032572` - Evaluation of the Safety and Effectiveness of the VRS100 System in PCI (ESSENCE)	N/A
Recruiting	`NCT05846893` - Drug-Coated Balloon vs. Drug-Eluting Stent for Clinical Outcomes in Patients With Large Coronary Artery Disease	N/A
Completed	`NCT04153006` - Comparison of Fingerstick Versus Venous Sample for Troponin I.
Completed	`NCT01205776` - EXCEL Clinical Trial	N/A
Active, not recruiting	`NCT04555174` - BIOFLOW-VIII All-comers Orsiro Mission Safety and Performance Registry
Recruiting	`NCT04582877` - Pressure Guidewire System Multi-center, Prospective, Self-Control, Clinical Trial	N/A
Recruiting	`NCT04390672` - Multivessel TALENT	N/A
Recruiting	`NCT03265535` - Validation of a Single Rest-Stress Imaging Protocol for Myocardial Perfusion Imaging
Not yet recruiting	`NCT04522583` - Increased CRP Concentrations in Patients Admitted to the Emergency Department With Troponin Elevation Aids to Rule Out Coronary Ischemia
Completed	`NCT02554006` - Predischarge Bundle to Minimize Negative Impact on Quality of Life of Nuisance Bleedings	N/A
Terminated	`NCT02407626` - Optimization of Cardioprotection in Diabetic Patients Undergoing Cardiac Surgery	N/A
Completed	`NCT02510547` - Comparison of a CrossBoss First Versus Standard Wire Escalation Strategy for Crossing Coronary Chronic Total Occlusion: the "CrossBoss First" Trial	Phase 4
Active, not recruiting	`NCT02189499` - Feasibility Study of the Amaranth Medical FORTITUDE Bioresorbable Drug-Eluting Coronary Stent	Phase 2
Completed	`NCT02264717` - Dan-NICAD - Danish Study of Non-Invasive Diagnostic Testing in Coronary Artery Disease	N/A
Completed	`NCT02197065` - Pilot Study of Atorvastatin for Orthopedic Surgery Patients	Phase 2
Recruiting	`NCT01681381` - Evaluate Safety And Effectiveness Of The Tivoli® DES and The Firebird2® DES For Treatment Coronary Revascularization	N/A
Terminated	`NCT01892917` - BIOFLOW-III Hungary Satellite Registry	N/A
Completed	`NCT01679886` - Comparison of Rubidium PET and SPECT With CZT Crystals for Detection of Myocardial Ischemia in Overweighed Patients and Women	N/A
Completed	`NCT01655043` - Absolute Quantification of Coronary Flow Reserve by Stress Perfusion MRI	Phase 2
Completed	`NCT02707445` - Genotyping Influences Outcome of Coronary Artery Stenting	N/A

The Association Between Systemic Microvascular Endothelial Function and Coronary Physiology Indexes

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms