Myocardial Ischemia Clinical Trial
Official title:
Remote Ischemic Preconditioning in Patients Undergoing Isolated Aortic Valve Replacement Surgery With a Biological Prosthesis: A Single Center Randomized Prospective Study
The goal is to investigate the efficacy, safety and possible neuro- and cardioprotective
effects of remote ischemic preconditioning (RIPC) in adult cardiac patients undergoing
isolated aortic valve replacement surgery with a biological prosthesis. Neuropsychological
evaluation preoperatively and at 30d after surgery will establish if there are any
differences in neuropsychological performance between groups. A large array of biochemical
markers will be analyzed from plasma samples taken at different time points. Additionally
skin biopsies from the lower limb will be taken before and after performing RIPC on said
limb. During the venous cannulation phase a atrial biopsy will be taken. The biochemical
markers from plasma and tissue samples will be used to asses brain tissue damage,
inflammation and cardiac tissue damage between groups.
This will be a single center prospective randomized study with two groups. A intervention
group (RIPC) and a control group. Study size is: 40 patients in total, 20 patients per group.
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