The Acute Cardiovascular Effects of Marathon Running Using Magnetic Resonance Imaging

Myocardial Ischemia Clinical Trial

— MARATHON-MRI  

Official title:

The Acute Cardiovascular Effects of Marathon Running Using Magnetic Resonance Imaging

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00752752
• Other study ID #: HIC2008-083
• Status: Completed
• Phase: N/A
• First received: September 12, 2008
• Last updated: April 2, 2012
• Start date: September 2008
• Est. completion date: May 2010

Study information

• Verified date: April 2012
• Source: William Beaumont Hospitals
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

Using blood testing and cardiac magnetic resonance imaging (MRI), the investigators aim to determine if there are necrotic areas of myocardium in participants who complete a marathon. In addition, the investigators aim to describe the acute and chronic structural abnormalities that occur as a result of endurance training. The study hypothesis is that myocardial necrosis is present in runners completing a marathon competition.

Description:

MARATHON-MI is a prospective, observational study of twenty-five (25) participants with plans of completing the Detroit Free Press Marathon in Detroit, Michigan on October 19, 2008. All participants will undergo a rigorous pre-marathon screening process which will include: 1) blood testing, 2) complete cardiopulmonary exercise testing, 3) ECG testing, 4) Holter monitoring, 5) cardiac MRI. Blood work will be check after the marathon immediately after and one day after the event. Cardiac MRI will be repeated within 12 hours of finishing the marathon. Using the information derived from the blood work and radiological testing, we will attempt to determine if there is an association between marathon running and myocardial necrosis.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 25
• Est. completion date: May 2010
• Est. primary completion date: May 2010
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 60 Years

Eligibility

Inclusion Criteria:

• Detroit Free Press Marathon participant on October 19, 2008,

• Age > 18 years old,

• Ability to provide informed consent.

Exclusion Criteria:

• Known coronary or structural heart disease

• Pregnancy,

• Extreme claustrophobia,

• Metal implants,

• Renal dysfunction.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Coronary Artery Disease
• Elevated Cardiac Enzymes
• Left Ventricular Systolic Dysfunction
• Myocardial Ischemia
• Ventricular Dysfunction, Left

Locations

Country	Name	City	State
United States	William Beaumont Hospital	Royal Oak	Michigan

Sponsors (1)

Lead Sponsor	Collaborator
William Beaumont Hospitals

Country where clinical trial is conducted

United States,