Beta-blocker Before Extubation

Status Withdrawn

Clinical Trial Summary

Silent myocardial ischemia is known to occur in the general medical intensive care unit population immediately following tracheal extubation. We believe these patients are at risk for primary cardiac events in the 4 hours immediately following extubation. Metoprolol is a selective beta-1 antagonist, with little to no beta-2 activity at low and moderate doses. The cardioprotective effects of beta blockade have been well documented in randomized controlled trials. In patients undergoing extubation, prophylactic use of intravenous metoprolol may reduce post-extubation ischemia events as well as precursors of cardiogenic pulmonary edema (atrial and ventricular wall tension). Our primary hypothesis is that prophylactic metoprolol (titrated to reduce resting heart rate by at least 10%) prior to tracheal extubation will reduce the rate of ischemia as judged by ST segment analysis.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT00563238
Study type	Interventional
Source	University of Iowa
Contact
Status	Withdrawn
Phase	N/A
Start date	November 2007
Completion date	December 2009

View Details

See also
Status	Clinical Trial	Phase
Not yet recruiting	`NCT06032572` - Evaluation of the Safety and Effectiveness of the VRS100 System in PCI (ESSENCE)	N/A
Recruiting	`NCT05846893` - Drug-Coated Balloon vs. Drug-Eluting Stent for Clinical Outcomes in Patients With Large Coronary Artery Disease	N/A
Completed	`NCT04153006` - Comparison of Fingerstick Versus Venous Sample for Troponin I.
Completed	`NCT01205776` - EXCEL Clinical Trial	N/A
Active, not recruiting	`NCT04555174` - BIOFLOW-VIII All-comers Orsiro Mission Safety and Performance Registry
Recruiting	`NCT04582877` - Pressure Guidewire System Multi-center, Prospective, Self-Control, Clinical Trial	N/A
Recruiting	`NCT04390672` - Multivessel TALENT	N/A
Recruiting	`NCT03265535` - Validation of a Single Rest-Stress Imaging Protocol for Myocardial Perfusion Imaging
Not yet recruiting	`NCT04522583` - Increased CRP Concentrations in Patients Admitted to the Emergency Department With Troponin Elevation Aids to Rule Out Coronary Ischemia
Terminated	`NCT02407626` - Optimization of Cardioprotection in Diabetic Patients Undergoing Cardiac Surgery	N/A
Completed	`NCT02510547` - Comparison of a CrossBoss First Versus Standard Wire Escalation Strategy for Crossing Coronary Chronic Total Occlusion: the "CrossBoss First" Trial	Phase 4
Completed	`NCT02554006` - Predischarge Bundle to Minimize Negative Impact on Quality of Life of Nuisance Bleedings	N/A
Active, not recruiting	`NCT02189499` - Feasibility Study of the Amaranth Medical FORTITUDE Bioresorbable Drug-Eluting Coronary Stent	Phase 2
Completed	`NCT02197065` - Pilot Study of Atorvastatin for Orthopedic Surgery Patients	Phase 2
Completed	`NCT02264717` - Dan-NICAD - Danish Study of Non-Invasive Diagnostic Testing in Coronary Artery Disease	N/A
Recruiting	`NCT01681381` - Evaluate Safety And Effectiveness Of The Tivoli® DES and The Firebird2® DES For Treatment Coronary Revascularization	N/A
Terminated	`NCT01892917` - BIOFLOW-III Hungary Satellite Registry	N/A
Completed	`NCT01679886` - Comparison of Rubidium PET and SPECT With CZT Crystals for Detection of Myocardial Ischemia in Overweighed Patients and Women	N/A
Completed	`NCT01655043` - Absolute Quantification of Coronary Flow Reserve by Stress Perfusion MRI	Phase 2
Completed	`NCT01434043` - Diagnostic Accuracy of Cardiac CT Perfusion Compared to PET Imaging