Myocardial Ischemia Clinical Trial
Official title:
Double-blind Phase II Pilot Monocentric Randomized Clinical Trial Evaluating the Effect of a Preliminary Administration of Erythropoietin on Different Markers of Cardiac Ischemia Induced by Cardiopulmonary Bypass
The main objective is to observe the effects of erythropoietin administration on different blood markers of ischaemic cardiac lesions induced by cardiopulmonary bypass.
A new property of erythropoietin (EPO), independent of its hematopoietic role, has recently
been discovered. Indeed, it has been reported that this hormone, following binding to its
cardiac or cerebral receptors, is able to induce a spectacular cellular protection against
ischemic injury. These cardioprotective and neuroprotective effects have been observed
experimentally in rodents as well as clinically in humans. In particular, our team has
demonstrated that the administration of NeoRecormon® protects the heart against ischemia in
the rat by significantly improving its recovery.
In view of these exciting experimental results and of the growing interest of the scientific
community for cytoprotective effects of EPO, we are planning the first clinical study
examining the cardiac and cerebral protective effects of EPO (NeoRecormon®) in the setting
of cardiac surgery.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention
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