Myocardial Injury Clinical Trial
Official title:
Cardioprotective of Electroacupuncture Pretreatment in Patients Underwent Coronary Stenting: A Prospective, Multicenter, Randomized Control Trial
Myocyte necrosis as a result of elective percutaneous coronary intervention (PCI) occurs in approximately one third of cases and is associated with subsequent cardiovascular events. This study assesses the ability of electroacupuncture (EA) pretreatment to attenuate cardiac troponin I (cTnI) release after elective PCI.
Elective percutaneous coronary intervention (PCI) is associated with troponin release in
approximately one third of cases.Troponin release is a sensitive and specific marker of
myocyte necrosis and infarction resulting from a form of ischemia/reperfusion injury,
downstream embolization of atheromatous material, and coronary side-branch occlusion. A
number of studies have demonstrated that procedure-related troponin release is associated
with subsequent cardiovascular events.
Transient sublethal episodes of ischemia before a prolonged ischemia/reperfusion injury,
known as ischemic preconditioning (IPC), have been shown to reduce the extent of myocardial
infarction (MI).Electroacupuncture (EA) stimulus, as a pretreatment method, limits MI size
in animal models. However, there are limited outcome to demonstrate protection from EA
pretreatment during PCI. The present study investigated the ability of EA pretreatment to
attenuate cardiac troponin I (cTnI) release after elective PCI in a single-center,
randomized controlled trial.
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Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Prevention
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