Myocardial Injury Clinical Trial
Official title:
Cardioprotective of Electroacupuncture Pretreatment in Patients Underwent Coronary Stenting: A Prospective, Multicenter, Randomized Control Trial
Myocyte necrosis as a result of elective percutaneous coronary intervention (PCI) occurs in approximately one third of cases and is associated with subsequent cardiovascular events. This study assesses the ability of electroacupuncture (EA) pretreatment to attenuate cardiac troponin I (cTnI) release after elective PCI.
Elective percutaneous coronary intervention (PCI) is associated with troponin release in
approximately one third of cases.Troponin release is a sensitive and specific marker of
myocyte necrosis and infarction resulting from a form of ischemia/reperfusion injury,
downstream embolization of atheromatous material, and coronary side-branch occlusion. A
number of studies have demonstrated that procedure-related troponin release is associated
with subsequent cardiovascular events.
Transient sublethal episodes of ischemia before a prolonged ischemia/reperfusion injury,
known as ischemic preconditioning (IPC), have been shown to reduce the extent of myocardial
infarction (MI).Electroacupuncture (EA) stimulus, as a pretreatment method, limits MI size
in animal models. However, there are limited outcome to demonstrate protection from EA
pretreatment during PCI. The present study investigated the ability of EA pretreatment to
attenuate cardiac troponin I (cTnI) release after elective PCI in a single-center,
randomized controlled trial.
;
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Investigator, Outcomes Assessor), Primary Purpose: Prevention
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Terminated |
NCT03940651 -
Cardiac and Renal Biomarkers in Arthroplasty Surgery
|
Phase 4 | |
| Completed |
NCT01688648 -
Comparison Between Lidocaine, Dexmedetomidine, and Their Combined Infusion in Subjects Undergoing Coronary Artery Bypass Graft
|
N/A | |
| Completed |
NCT04794062 -
Myocardial Injury and Quality of Life After COVID-19
|
||
| Recruiting |
NCT04750616 -
NAD+ Augmentation in Cardiac Surgery Associated Myocardial Injury Trial
|
Phase 2 | |
| Recruiting |
NCT04615871 -
Semaglutide to Reduce Myocardial Injury in PATIents With COVID-19
|
Phase 2 | |
| Withdrawn |
NCT04139655 -
Colchicine Prevents Myocardial Injury After Non-Cardiac Surgery Pilot Study
|
N/A | |
| Completed |
NCT05691764 -
Effect of Cyclosporine and Remote Ischemic Preconditioning in Reperfusion Ischemia Injury on Tetralogy Fallot Patients With Correction Surgery
|
N/A | |
| Completed |
NCT04436016 -
PeRiOperaTivE CardioproTection With Ivabradine in Non-cardiac Surgery
|
Phase 4 | |
| Recruiting |
NCT05748691 -
Switching From Cardiac Troponin I to T
|
||
| Completed |
NCT03338504 -
Determining the Mechanism of Myocardial Injury and Role of Coronary Disease in Type 2 Myocardial Infarction
|
||
| Recruiting |
NCT03013634 -
Protective Effects of Dexmedetomidine on Myocardial Injury During Liver Transplantation
|
N/A | |
| Completed |
NCT00007358 -
Dexamethasone Treatment for Congenital Heart Block (CHB) in Newborns With Lupus
|
N/A | |
| Recruiting |
NCT05714618 -
MR Evidence of Cardiac Inflammation Post-Stroke
|
||
| Recruiting |
NCT04624503 -
Prognostic and Clinical Impact of Cardiovascular Involvement in Patients With COVID-19
|
||
| Active, not recruiting |
NCT03339180 -
Cardiac Injury in Patients With Influenza
|
||
| Completed |
NCT03010839 -
Cardiopulmonary Protective Effects of Modified Remote Ischaemic Preconditioning in Mitral Valve Replacement Surgery
|
N/A | |
| Recruiting |
NCT04743765 -
HIP Fracture Accelerated Surgical TreaTment And Care tracK 2 Trial
|
N/A | |
| Enrolling by invitation |
NCT03253835 -
Cardiac Blood Flow Patterns Associated With Left Ventricular Myocardial Damage
|
||
| Completed |
NCT00817791 -
Preconditioning With Hyperbaric Oxygen in Cardiovascular Surgery
|
N/A | |
| Completed |
NCT04149314 -
The "Hypotension Prediction Index" in Patients Undergoing Lung Surgery
|
N/A |