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Protective Effects of Dexmedetomidine on Myocardial Injury During Liver Transplantation

Myocardial Injury Clinical Trial

Clinical Trial Summary

The purpose of this study was to evaluate the protective effect of dexmedetomidine on myocardial injury during liver transplantation

Clinical Trial Description

Liver transplantation surgery may lead to myocardial injury. Dexmedetomidine, a highly specific α2-adrenoeptor agonist, has sedative and analgesic properties without significant respiratory depression at the clinically approved dosage. Some investigations indicated that dexmedetomidine was able to protect the myocardium via improving the activity of Na+-K+-adenosine triphosphate enzyme and Ca2+-adenosine triphosphate, alleviating inflammation reaction and avoiding Ca2+ overload. However, the effect and the mechanism of dexmedetomidine on myocardial injury during liver transplantation remain unclear. ;

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Prevention

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03013634
Study type Interventional
Source Tianjin First Central Hospital
Contact Wenli Yu, PhD
Phone 86-13920098326
Email yzxyuwenli@163.com
Status Recruiting
Phase N/A
Start date October 2016
Completion date November 2017
View Details
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