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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT05860504
Other study ID # SCCCS
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date May 29, 2023
Est. completion date March 30, 2026

Study information

Verified date October 2023
Source Sahlgrenska University Hospital, Sweden
Contact Jonatan Oras, MD, PhD
Phone +46313421000
Email jonatan.oras@vgregion.se
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The overall aim of the study is to establish the clinical importance of cardiac dysfunction, by estimating its incidence and impact on short- and long-term outcomes, in a mixed population of critically ill patients with multi-organ failure. Pathogenesis of cardiac dysfunction in critical illness and key molecules linked to this will be explored.


Description:

During critical illness, the heart is exposed to extreme external stressors, which may contribute to heart failure. There is a lack of knowledge of what happens to the heart over the course of critical illness. The few studies available suggest that LV dysfunction is common in critical illness, with a prevalence of 10-30%. Notably, LV regional hypokinesia is a frequent pattern of LV dysfunction among these patients and is associated with a higher risk of death. LV regional hypokinesia during critical illness may have several possible aetiologies, including ischemic, inflammatory or other/mixed processes. Of these, acute coronary artery obstruction is probably most important. Patients with sepsis, for example, and acute ST elevation myocardial infarction have twice the risk of death. Type II myocardial infarction can also lead to LV dysfunction due to insufficient coronary artery flow e.g., from tachycardia, hypotension and hypoxia, resulting in myocardial ischemia. In the absence of CAD, LV regional hypokinesia could also result from myocardial inflammation secondary to systemic inflammatory response, direct toxic effects of cytokines or pathogenic infiltration. Another possible aetiology is Takotsubo syndrome, an acute cardiac condition characterised by reversible regional hypokinesia, usually in the apical portion of the LV. The current paradigm suggests that Takotsubo syndrome is triggered by the overstimulation of the myocardium by catecholamines and is closely correlated to events involving severe emotional or physical stress. Cardiac dysfunction in critical illness is likely a phenotype of Takotsubo syndrome since patients in the ICU undergo extreme stress and are exposed to both endogenously-released and exogenously-administered catecholamines. In critical illness, accurate diagnosis of LV dysfunction is challenging due to the similar clinical presentation of potential aetiologies. However, diagnosing the underlying aetiology of LV dysfunction is essential to provide appropriate treatment and optimise outcomes. CAD can be diagnosed with coronary angiography and cardiac computed tomography (CCT). In the absence of CAD, cMRI is useful. cMRI can differentiate between myocardial ischemia, and inflammation, as well as between an acute or past event. In this study, patients are examined with echocardiography to identify those with cardiac dysfunction. In a sub-set of patients with LV dysfunction, patients will be examined with coronary CT (if no angiography performed) and cardiac MRI. Blood samples are collected for storage in biobank.


Recruitment information / eligibility

Status Recruiting
Enrollment 592
Est. completion date March 30, 2026
Est. primary completion date December 31, 2025
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: 1. Patients aged > 18 years 2. Admitted to a participating ICU within 24 hours 3. Significant organ dysfunction involving at least two organ systems. This is defined as fulfilling both of the following: - At least 4 points on the SOFA scale (Sequential Organ Failure Assessment scale) - Having at least 1 point on the SOFA scale from at least two organ systems 4. Given informed consent from patient or permission to participate from next of kin Exclusion Criteria: 1. Echocardiographic examination not possible (e.g., pneumothorax, draping etc) or very low echocardiographic examination quality 2. Not being examined with echocardiography within 24 hours from inclusion 3. Retracted consent to participate

Study Design


Intervention

Diagnostic Test:
Echocardiography
All patients in the study will be examined with echocardiography
Cardiac magnetic resonance imaging
Sub-group of patients with left ventricular systolic dysfunction will be examined with cMRI
Coronary CT
Sub-group of patients with left ventricular systolic dysfunction will be examined with CCT

Locations

Country Name City State
Sweden Sahgrensak University Hospital Västra Frölunda Please Select

Sponsors (1)

Lead Sponsor Collaborator
Sahlgrenska University Hospital, Sweden

Country where clinical trial is conducted

Sweden, 

Outcome

Type Measure Description Time frame Safety issue
Primary 90-days mortality Death 90 days
Secondary Alive outside ICU Days alive while not in the ICU 90 days
Secondary Alive without mechanical ventilation Days alive and without mechanical ventilation 90 days
Secondary Alive without CRRT Days alive without CRRT 90 days
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