Long-term Beta-blocker Therapy After Acute Myocardial Infarction

Status Recruiting

Clinical Trial Summary

The aim of the study is to determine whether discontinuation of β-blocker after at least 1 year of β-blocker therapy is noninferior to continuation of β-blocker in patients without heart failure (HF) or left ventricular systolic dysfunction after acute myocardial infarction (AMI). Prospective, open-label, randomized, multicenter, noninferiority trial to determine whether discontinuation of β-blocker after at least 1 year of β-blocker therapy is noninferior to continuation of β-blocker in patients without HF or left ventricular systolic dysfunction after AMI.

Clinical Trial Description

β-blockers have anti-ischemic, anti-arrhythmic, and anti-adrenergic properties. In order to reduce cardiovascular mortality and morbidity, current major guidelines recommend that oral treatment of β-blockers should be continued during and after hospitalization in patients with acute myocardial infarction (AMI) and without contraindications to β-blocker use. A clinically important but difficult decision on β-blocker therapy after AMI is to determine the duration of β-blocker therapy after discharge in patients without heart failure (HF) or left ventricular systolic dysfunction. Previous studies for long-term β-blocker therapy after AMI were inadequate to derive definite conclusion because of small sample size and potential selection bias. Therefore, the SMART-DECISION trial will investigate whether discontinuation of β-blocker after at least 1 year of β-blocker therapy is noninferior to continuation of β-blocker in patients without HF or left ventricular systolic dysfunction after AMI. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT04769362
Study type	Interventional
Source	Samsung Medical Center
Contact	Joo-Yong Hahn, MD,PhD
Phone	82-2-3410-6653
Email	jyhahn@skku.edu
Status	Recruiting
Phase	Phase 4
Start date	May 4, 2021
Completion date	March 20, 2026

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Long-term Beta-blocker Therapy After Acute Myocardial Infarction — SMART-DECISION

Clinical Trial Summary

Clinical Trial Description

Study Design

Related Conditions & MeSH terms