Myocardial Infarction Clinical Trial
— CODE-MIOfficial title:
Hs-cTn - Optimizing the Diagnosis of Acute Myocardial Infarction/Injury in Women
The project is focussed on evaluating the impact of using a female-specific threshold in the diagnosis of myocardial infarction. This female threshold is lower than the overall hs-cTn threshold currently in use. The investigators hypothesize that this change in process, applied at the hospital level, will lead to better assessment, treatment and outcomes of women presenting to the emergency department with chest pain that is cardiac in nature.
Status | Recruiting |
Enrollment | 24000 |
Est. completion date | December 2023 |
Est. primary completion date | December 2022 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 20 Years and older |
Eligibility | Inclusion Criteria: - >20 years of age - Present to the ED with chest pain or shortness of breath suggestive of ischemia - Have a valid personal health identifier - Have 1 hs-cTn test result Exclusion Criteria: - Have ST elevation myocardial infarction (STEMI) - Not residents in the same province as the hospital ED to which they present or move out of province within a year |
Country | Name | City | State |
---|---|---|---|
Canada | St. Paul's Hospital | Vancouver | British Columbia |
Lead Sponsor | Collaborator |
---|---|
BC Centre for Improved Cardiovascular Health | Canadian Institutes of Health Research (CIHR) |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Number of patients with all-cause mortality, non-fatal myocardial infarction, hospitalization for incident heart failure, or urgent/emergent coronary revascularization (percutaneous coronary intervention or coronary artery bypass surgery) | 1-year post index emergency department presentation | ||
Secondary | Number of patients with a) Non-fatal myocardial infarction or all-cause mortality; b) Urgent/emergent coronary revascularization or all-cause mortality; c) Hospitalization for heart failure or all-cause mortality. | 1-year post index emergency department presentation | ||
Secondary | Proportion of patients who fill at least one prescription for evidence-based cardiac medications | Medications include beta-blockers, Angiotensin Converting Enzyme (ACE)-I/Angiotensin II receptor blockers (ARB), statins, anti-platelets | Within 90 days of ED visit | |
Secondary | Proportion of patients who undergo diagnostic tests | Diagnostic tests include nuclear medicine cardiac scan, exercise stress test, diagnostic cardiac catheterization/CT angiogram or echocardiogram | Within 90 days of ED visit |
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