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Adjunctive, Low-dose tPA in Primary PCI for STEMI — STRIVE  

Myocardial Infarction Clinical Trial

Official title:
Adjunctive, Low-dose Intracoronary Recombinant Tissue Plasminogen Activator (tPA) Versus Placebo for Primary PCI in Patients With ST-segment Elevation Myocardial Infarction

Clinical Trial Summary

STRIVE will evaluate the use of adjunctive, low-dose intracoronary tissue plasminogen activator during primary percutaneous coronary intervention (PCI) for patients with ST elevation myocardial infarction (STEMI) in reducing the incidence of post-procedural myocardial blush (MBG) grade 0/1 or distal embolization.

Clinical Trial Description

STRIVE is a prospective, 3-arm, parallel group, blinded, randomized controlled trial evaluating the efficacy of a novel approach to prevent and treat microvascular obstruction thereby reducing major cardiovascular events using intracoronary administration of very low-dose fibrinolytic (tissue plasminogen activator, tPA) directly into the culprit coronary artery during primary PCI. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03335839
Study type Interventional
Source Population Health Research Institute
Contact Jennifer Cunningham
Phone 905-527-4322
Email strive@phri.ca
Status Recruiting
Phase Phase 3
Start date April 1, 2018
Completion date September 2024
View Details
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