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Effect of Beta-blocker on Cardioprotective Effect of Remote Ischemic Conditioning

Myocardial Infarction Clinical Trial

Official title:
Effect of Beta-blocker on Cardioprotective Effect of Remote Ischemic Conditioning

Clinical Trial Summary

Remote ischemic conditioning has been shown to protect myocardium from ischemia-reperfusion injury during cardiac intervention or cardiac surgery. However, effect of beta-blocker, commonly used cardiovascular medication in patients with cardiac diseases such as hypertension or angina pectoris, on cardioprotective role of remote ischemic conditioning has not been well documented. The purpose of the study is to investigate the effect of beta-blocker on remote ischemic conditioning in healthy volunteers.

Clinical Trial Description

This study is prospective cross-over study investigating effect of beta-blocker on cardioprotective role of remote ischemic conditioning. Eleven male healthy volunteers are going to take oral beta-blocker (carvedilol, 12.5 mg once) or not before undergoing remote ischemic conditioning (consisting of 4 cycles of 5-min ischemia and subsequent 5-min reperfusion of upper arm), separated by 6-day wash-out period. To evaluate cardioprotective effect of remote ischemic conditioning, blood samples will be obtained before and after remote ischemic conditioning. Form the samples, human dialysate will be obtained and be perfused to rat heart through Langendorff apparatus before ischemia-reperfusion injury to the rat heart. Changes of infarct size of the rat heart will be compared between the beta-blocker and control groups. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03169426
Study type Interventional
Source Seoul National University Hospital
Contact
Status Completed
Phase Phase 4
Start date May 17, 2017
Completion date November 10, 2017
View Details
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