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Antiplatelet Therapy Effect on Extracellular Vesicles in Acute Myocardial Infarction — AFFECT EV  

Myocardial Infarction Clinical Trial

Official title:
Antiplatelet Therapy Effect on Platelet Extracellular Vesicles in Acute Myocardial Infarction

Clinical Trial Summary

Platelet activation and aggregation leads to myocardial infarction. Platelet P2Y12 receptors are essential for platelet activation. Antagonists against the P2Y12 receptor, which are established in secondary prevention of myocardial infarction, have unexplained anti-inflammatory effects. A novel P2Y12 receptor antagonist ticagrelor reduced infection-related mortality compared to clopidogrel, previous standard treatment for patients with myocardial infarction. Activated platelets release pro-inflammatory and procoagulant platelet extracellular vesicles. The investigators assume that decrease in infection-related mortality in patients treated with ticagrelor may be explained by greater inhibition of the release of platelet vesicles by ticagrelor, compared to clopidogrel. This study is expected to identify an additional mechanism of action of ticagrelor, which might contribute to the observed clinical benefits in patients treated with ticagrelor.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02931045
Study type Interventional
Source Medical University of Warsaw
Contact
Status Completed
Phase Phase 4
Start date December 30, 2017
Completion date December 30, 2019
View Details
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