Genetic Variation in Platelet Aggregation

Status Completed

Clinical Trial Summary

The aim of the study is to test whether genetic variation in the alpha 2A adrenergic receptor affects diurnal variation in platelet aggregation.

Clinical Trial Description

There is a marked diurnal fluctuation in the occurrence of acute myocardial infarction and sudden death, with peak incidences occurring in the early morning. Platelet aggregation has also been shown to increase in the early morning. The investigators will test the hypothesis that alpha 2a-adrenergic receptor (ADRA2A) genetic variation, specifically haplotype 4, affects platelet aggregation. The investigators will compare diurnal platelet aggregation in haplotype 4 subjects with subjects in the other haplotype families. In addition, the investigators will compare platelet aggregation after the cold pressor test in haplotype 4 with the other haplotype families. If there are no differences among haplotypes, then the haplotypes will be combined to analyze. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT01576536
Study type	Observational
Source	Vanderbilt University Medical Center
Contact
Status	Completed
Phase
Start date	July 2012
Completion date	December 2016

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