Myocardial Infarction Clinical Trial
Official title:
Feasibility of High Frequency QRS Analysis in Patients With Acute Myocardial Infarction
The primary objective of this study is to characterize the morphological patterns of high frequency QRS components (HFQRS) in patients with acute myocardial infarction (AMI), including STEMI and NSTEMI, compared to patients without AMI.
Chest pain is one of the leading reasons of hospital emergency department (ED) visits
worldwide. In the US, approximately 6 million people annually undergo evaluation in the ED
for acute chest pain. Despite the wealth of knowledge available about acute coronary
syndrome (ACS), this condition continues to be among the most difficult to predict or
diagnose. Misdiagnoses may lead to discharge of patients with ACS, who should have been
admitted as well as costly unnecessary hospitalizations of patients who do not have ACS.
More than 2/3 of the patients with ACS have unstable angina (UA) or non-ST-elevation
myocardial infarction (NSTEMI). Conventional ECG has low sensitivity of less than 50% in
diagnosing these conditions. As the initial ECG in the ED is often non-diagnostic in ACS
patients, the diagnosis of ST-elevation myocardial infarction (STEMI) during its early
stages may also be difficult.
Analysis of high-frequency QRS components (HFQRS), which quantifies changes in the
depolarization phase of the cardiac cycle, has been previously reported to be a sensitive
method for detection of demand ischemia. Preliminary studies have shown that HFQRS-derived
indices can also identify supply ischemia caused by prolonged balloon occlusion, and
transient ischemic episodes in patients with chest pain.
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Observational Model: Case Control, Time Perspective: Prospective
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