The Relationship Between the Response to Mental Stress and Vascular Endothelial Function

Myocardial Infarction Clinical Trial

Official title:

The Relationship Between the Response to Mental Stress and Vascular Endothelial Function

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00975559
• Other study ID #: 1881-03
• Status: Completed
• Phase: N/A
• First received: September 9, 2009
• Last updated: April 25, 2012
• Start date: September 2003
• Est. completion date: April 2011

Study information

• Verified date: April 2012
• Source: Mayo Clinic
• Contact: n/a
• Is FDA regulated: No
• Health authority: United States: Institutional Review Board
• Study type: Observational

Clinical Trial Summary

The aim of this study is to measure how different people respond to mental stress. The investigators will measure if there are differences in cardiovascular responses to mental stress among different groups of subjects. In one part of the study the investigators will compare the cardiovascular responses to mental stress between healthy women and healthy men. In another part of the study, the investigators will compare the cardiovascular responses to mental stress between women with apical ballooning syndrome and healthy post-menopausal women. The investigators hypothesize that healthy men will have an increased vascular response to and decreased endothelial function in response to to mental stress, compared to health women. Furthermore, the investigators hypothesize that women with apical ballooning syndrome will have an increased vascular response to and decreased endothelial function in response to mental stress.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 190
• Est. completion date: April 2011
• Est. primary completion date: April 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Patients must be identified in one of the four groups outlined in "study population description."

Exclusion Criteria:

• Other co-morbidities that would make the testing not possible.

• Women who have had a mastectomy and would not have an arm that could be occluded during the reactive hyperemia portion of the Peripheral arterial tonometry testing.

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

• Apical Ballooning Syndrome
• Coronary Endothelial Dysfunction
• Myocardial Infarction
• Stress, Psychological
• Takotsubo Cardiomyopathy

Locations

Country	Name	City	State
United States	Mayo Clinic	Rochester	Minnesota

Sponsors (2)

Lead Sponsor	Collaborator
Mayo Clinic	United States Department of Defense

Country where clinical trial is conducted

United States,