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Pharmacological Postconditioning to Reduce Infarct Size Following Primary PCI — POSTCON II  

Myocardial Infarction Clinical Trial

Official title:
Pharmacological Postconditioning to Reduce Infarct Size Following Primary PCI in Patients With STEMI

Clinical Trial Summary

Both pre- and postconditioning seem to protect cardiomyocytes during reperfusion therapy. Investigations both ex vivo and in vivo suggest that a gut derived hormone, Glucagon-Like-Peptide-1 (GLP-1), is able to reduce reperfusioninjury after myocardial ischemia. Results from our own laboratory have shown a marked reduction in infarct size when rat hearts in a Langendorf preparation were exposed to the GLP-1 analogue, exendin-4. The investigators want to investigate to what extent this effect can be translated to humans in the setting of acute STEMI treated with primary PCI when evalutaed by cardiac magnetic resonance imaging.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00835848
Study type Interventional
Source Rigshospitalet, Denmark
Contact
Status Completed
Phase Phase 4
Start date January 2009
Completion date May 2015
View Details
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