Myocardial Infarction Clinical Trial
Official title:
Non Invasive Positive Airway Pressure And Risk Of Myocardial Infarction In Acute Cardiogenic Pulmonary Edema: Continuous Positive Airway Pressure Vs Non Invasive Positive Pressure Ventilation
This randomized controlled trial is primarily aimed at assessing the rate of acute myocardial infarction with the two noninvasive ventilatory techniques, non-invasive intermittent positive pressure ventilation and non-invasive continuous positive airway pressure.
Objective: To determine whether the application of non-invasive intermittent positive
pressure ventilation (n-IPPV) increases the incidence of acute myocardial infarction (AMI)
in patients with acute respiratory failure (ARF) secondary to acute cardiogenic pulmonary
edema (ACPE), as opposed to non-invasive continuous positive airway pressure (n-CPAP).
Background Both n-CPAP or n-IPPV are used to treat ACPE complicated by ARF. Two previous
studies, however, report an increased rate of AMI associated with the use of n-IPPV.
Methods: Fifty-two patients with severe ARF consequent to ACPE were randomized to receive
n-CPAP (n=27) or n-IPPV (n=25), both associated with standard medical therapy. Cardiac
markers, electrocardiogram and clinical-physiological parameters were monitored at study
entry, after 30 and 60 minutes, and every 6 hours for the first two days.
;
Allocation: Randomized, Endpoint Classification: Safety Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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