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Ciclosporin A and Acute Myocardial Infarction

Myocardial Infarction Clinical Trial

Official title:
Protection by Ciclosporine A During Reperfused Acute Myocardial Infarction.

Clinical Trial Summary

Beyond its immunosuppressive properties, ciclosporine A (CsA) can also inhibit the opening of a mitochondrial mega-channel called the permeability transition pore (mPTP). Opening of the mPTP plays a key role in cardiomyocyte death during reperfusion following a prolonged ischemic insult. Ciclosporin A has been shown to reduce infarct size when administered at reperfusion in experimental models. The objective of the present study is to determine whether administration of CsA at reperfusion in patients with ongoing acute myocardial infarction treated by coronary angioplasty might reduce infarct size.

Clinical Trial Description

n/a

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment, Masking: Single Blind, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00403728
Study type Interventional
Source Hospices Civils de Lyon
Contact
Status Active, not recruiting
Phase Phase 2/Phase 3
Start date September 2004
View Details
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