Myocardial Infarction Clinical Trial
Official title:
The Japan Working Group for the Assessment That the Alpha-glucosidase Inhibitor Blocks Cardiac Events in Patients With Myocardial Infarction and IGT
The purpose of this study is to evaluate whether an alpha-glucosidase inhibitor, a drug for the suppression of postprandial hyperglycemia, could reduce the recurrence of myocardial infarction in patients with impaired glucose tolerance (IGT) and old myocardial infarction.
Type 2 diabetes mellitus is a well-established risk factor for coronary heart disease and
atherosclerotic change in the coronary artery develops subclinically in a state of impaired
glucose tolerance (IGT). Recently postprandial hyperglycemia as a feature of impaired glucose
tolerance is recognized as a significant risk factor for coronary heart disease. So we
designed a prospective randomized multi-center trial named Assessment of an
α-glucosidase-inhibitor to Block Cardiac Events in Patients With Myocardial Infarction and
IGT (ABC study) to evaluate whether an α-Glucosidase Inhibitor, a drug for the suppression of
postprandial hyperglycemia, could reduce the recurrence of myocardial infarction in patients
with IGT and old myocardial infarction.
100 hospitals will participate in the ABC study. Patients with IGT who have a history of
prior myocardial infarction are randomly allocated to receive α-Glucosidase Inhibitor
(voglibose) or a standard diet and exercise treatment. The number of patients to be recruited
is 3000 and this study will continue for at least 2 years. The primary end-points are:
1. cardiovascular mortality and
2. hospitalization for cardiovascular events.
Effects in suppression of new diabetes development will also be evaluated.
We should recognize IGT as an important therapeutic target to decrease the recurrence of
cardiovascular events. The ABC study, a large scale multi-center trial in Japan, will provide
us with new evidence on how to treat IGT patients with prior myocardial infarction.
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