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Myocardial Bridging clinical trials

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NCT ID: NCT06354413 Completed - Clinical trials for Coronary Artery Disease

Outcomes of Concomitant Bypass Surgery in Septal Myectomy

Start date: January 2009
Phase:
Study type: Observational

To investigate clinical characteristics and survival outcomes of patients with obstructive hypertrophic cardiomyopathy who underwent concomitant coronary artery bypass grafting during septal myectomy.

NCT ID: NCT06281067 Recruiting - Myocardial Bridge Clinical Trials

Reassessment of myocardIAL Bridge TOwards PeRsOnalized Medicine

RIALTO PRO
Start date: December 15, 2023
Phase: N/A
Study type: Interventional

The "RIALTO-PRO" study aims to optimize the diagnostic and therapeutic algorithm for myocardial bridge (MB) patients, testing the diagnostic value of a full invasive diagnostic procedure, and, consequently, the prognostic value of a tailored approach. the study objective is to determine the diagnostic and prognostic value of a full-physiology approach strategy versus a standard approach strategy in patients with a MB. The "RIALTO PRO" study is a randomized, multicentre, prospective, open-label, superiority trial comparing a personalised versus standard management in patients with MB. Consenting and eligible patients will be randomised 1:1 to either a "full-physiology approach", consisting of a comprehensive diagnostic algorithm aimed at unmasking the main pathophysiological mechanism of myocardial ischemia and consequently a tailored treatment, or a "standard approach", consisting of angiographic evaluation of the tunnelled segment.

NCT ID: NCT05111418 Completed - Myocardial Bridge Clinical Trials

Myocardial Bridge Evaluation Towards Personalised Medicine: the RIALTO Registry

RIALTO
Start date: March 17, 2021
Phase:
Study type: Observational [Patient Registry]

Myocardial bridge (MB) is a congenital anomaly of epicardial circulation characterized by an intramural course of a coronary segment. This anatomical arrangement causes the artery to be squeezed during systole potentially causing flow impairment and ischemia. For this study, MB is defined as the presence of systolic compression in an epicardial vessel causing at least 50% of caliber reduction from diastole. MB can be disabling as it worsens the quality of life. Early detection of this congenital condition is crucial, and an invasive functional assessment of the ischemic burden should be considered to evaluate the need for medical or surgical therapy. This is an observational study, involving four Italian centres. Study Objectives are: To assess the risk of future cardiovascular complications in patients with MB referred for coronary angiography and the role of beta-blocker therapy; To describe the clinical and anatomical characteristics of patients presenting with MB; To determine the impact of cardiovascular medications on symptoms in patients with MB; To describe the anatomical and clinical features associated with the invasive evidence of ischemia in patients with MB; To assess the relation between invasively documented ischemia and clinical manifestations in patients with the MB. Inclusion Criteria: patients referred to undergo ICA (for both elective or urgent indications) for suspected coronary artery disease found to have an MB with or without other epicardial lesions amenable to revascularization; Age above 18 y.o.; Ability to provide Informed Consent. Exclusion Criteria are Patients with life expectancy below 12 months and Patients with severe valvular heart disease. The primary endpoint is the incidence of MACE defined as the composite of cardiac death, myocardial infarction, cardiac hospitalization, and target vessel revascularization. The secondary endpoint is evaluating the Rate of patients with SAQ < 70 and the Rate of patients with "high-risk features" on CT scan.

NCT ID: NCT04958395 Completed - Myocardial Bridge Clinical Trials

Evaluation of the Hemodynamic Significance of Myocardial Bridge by Coronary Blood Fractional Flow Reserve

Start date: November 1, 2014
Phase:
Study type: Observational

This study clarified the influence of myocardial bridge on coronary hemodynamics by clarifying FFR and d-FFR to guide clinical intervention and treatment.

NCT ID: NCT04869150 Completed - Clinical trials for Myocardial Bridge of Coronary Artery

Does Myocardial Bridge Appear More Frequently and Diffusely on Radial Access Coronary Angiography

Start date: February 8, 2018
Phase:
Study type: Observational [Patient Registry]

Although the incidence of myocardial bridge (MB) has been defined in different conventional coronary angiography (CCA) studies,the frequency of MB in radial access coronary angiography (RACA) is unknown.The aim of this study was to determine the incidence of MB in patients undergoing RACA.

NCT ID: NCT04827498 Recruiting - Myocardial Ischemia Clinical Trials

Myocardial Ischemia Without Obstructive Coronary Stenoses

Start date: November 8, 2017
Phase:
Study type: Observational

Coronary-related myocardial ischemia can result from obstructive epicardial stenosis or non-obstructive causes including coronary microcirculatory dysfunction and vasomotor disorders. This prospective study has been created in order to provide knowledge in the field of non-obstructive coronary artery disease.

NCT ID: NCT04664387 Completed - Clinical trials for Somatic Symptom Disorder

Somatic Symptom Disorders in Patients With Myocardial Bridge

Start date: October 30, 2016
Phase:
Study type: Observational

The purpose of this study was to investigate the prevalence of physical and mental disorder in the population of patients with myocardial bridge and to describe the relationship between clinical features and the occurrence of somatic disorder.

NCT ID: NCT04130438 Suspended - Myocardial Bridging Clinical Trials

Efficacy of Medical Therapy in Women and Men With Angina and Myocardial Bridging

Start date: October 15, 2020
Phase: Phase 2
Study type: Interventional

The proposed clinical trial is relevant to public health because it is expected to expand the differential diagnosis and provide an evidence--based therapy for the large population of patients with angina in the absence of obstructive CAD who currently remain undiagnosed and untreated. It, therefore, upholds an important part of the mission of the The National Heart, Lung, and Blood Institute (NHLBI), which is to promote the treatment of heart disease and enhance the health of all individuals so that they can live longer and more fulfilling lives.

NCT ID: NCT04082546 Completed - Clinical trials for Myocardial Bridge of Coronary Artery

Correlates of Left Ventricular Global Longitudinal Strain and Surgical Intervention on Myocardial Bridges

Start date: November 26, 2016
Phase:
Study type: Observational

To examine the changes in left ventricular (LV) global longitudinal strain (GLS), using two-dimensional speckle tracking analysis, after left anterior descending (LAD) unroofing, in myocardial bridges (MBs) refractory to optimal medical therapy (OMT).