PET/MRI in the Diagnosis of Chronic Pain

Status Recruiting

Clinical Trial Summary

Several studies have implicated involvement of sigma-1 receptors (SR1s) in the generation of chronic pain, while others are investigating anti SR1 drugs for treatment of chronic pain. Using [18F]-FTC-146 and positron emission tomography/magnetic resonance imaging (PET/MRI), the investigators hope to identify the source of pain generation in patients with chronic pain. The purpose of this study is to compare the uptake of [18F]FTC-146 in healthy volunteers to that of individuals suffering from chronic pain.

Clinical Trial Description

Chronic pain is a significant, widespread problem affecting every fifth person worldwide. Reported in 2011 by the Institute of Medicine, chronic pain affects 116 million American adults - more than the total number of individuals affected by heart disease, cancer, and diabetes combined. An estimated $635 billion each year is spent in the medical management of chronic pain and lost productivity. Better clinical methods to diagnose and localize pain are needed. The investigators have developed a S1R-specific radiotracer, [18F]FTC-146. Using imaging approaches to assess the location of S1R in pain may provide a tool to diagnose pain generators, monitor treatment response, and aid in the selection of patients for treatment. The goal is to use [18F]FTC-146 to image S1R expression in healthy volunteers and to compare the images to those individuals suffering from pain conditions in the following categories: (1) nociceptive pain (pain that results from tissue injury or inflammation), (2) neuropathic pain (pain that results from direct injury, disruption, impingement/compression or malfunction of the peripheral and/or central nervous system), and (3) mixed pain (pain that appears to have both nociceptive and neuropathic). ;

Study Design

Related Conditions & MeSH terms

Chronic Pain
Mixed Pain (Nociceptive and Neuropathic)
Myelopathy
Neuralgia
Neurogenic Claudication
Neuropathic Pain
Nociceptive Pain
Radiculopathy
Spinal Cord Diseases

Clinical Trial Details

NCT number	NCT03556137
Study type	Interventional
Source	Stanford University
Contact	Anand Veeravagu, MD
Phone	(650) 498-6154
Email	anand.veeravagu@stanford.edu
Status	Recruiting
Phase	Phase 1
Start date	July 16, 2018
Completion date	December 31, 2024

View Details

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