Myelofibrosis Clinical Trial
Official title:
Secondary Cancers in Myeloproliferative Neoplasms (MPN-K Study)
The incidence of secondary cancer (SC) in patients with myeloproliferative neoplasms (MPN) is high and comparable to that of thrombosis. However, the identification of patient subgroups that might be at increased susceptibility of developing SC has not been systematically addressed. This international case-control study (MPN-K) is aimed to elucidate the prognostic role of JAK2V617F mutation in predicting the occurrence of SC in patients with classical MPN, polycythemia vera (PV), essential thrombocythemia (ET) and myelofibrosis (MF)
For each recruited case with concomitant diagnosis of myeloproliferative neoplasms (MPN) and
secondary cancer each participating center will provide up 3 control patients (1 control for
each case could be accepted but the optimal number is 3). Controls are patients with
myeloproliferative neoplasms and no history of cancer. Each control will be matched to the
paired case for sex, age (+/- 3 years), date of MPN diagnosis (+/- 5 years), and MPN disease
duration (+/- 3 years).
Each control is censored at the date of the secondary cancer occurrence in his matched case
(index date).
Data will be collected retrospectively from pre-existing medical records and reported by each
center on a web-based and validated eCRF developed to record y all study data. In order to
maintain patient privacy, all data records will be treated anonymously and no personal data
to identify patient will be recorded: patients will be identified in the study by an
alphanumeric code.
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