Remote Evaluation of MIND Diet

Multiple Sclerosis Clinical Trial

— REMIND  

Official title:

Remote Evaluation of MIND Diet

Clinical Trial Details — Status: Not yet recruiting

Administrative data

• NCT number: NCT06450977
• Other study ID #: REMIND
• Status: Not yet recruiting
• Phase: N/A
• Start date: June 7, 2024
• Est. completion date: December 31, 2026

Study information

• Verified date: June 2024
• Source: University of Illinois at Urbana-Champaign
• Contact: Naiman Khan, PhD
• Phone: 2173001667
• Email: nakhan2[@]illinois.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The goal of this clinical trial is to learn if increasing adherence to a Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet pattern improves thinking ability and memory compared to a healthy control diet in persons with Multiple Sclerosis (MS). The main question it aims to answer is: Does the MIND diet improve cognitive performance relative to a control diet in persons with MS? Participants will: Consume one meal that follows the MIND diet or a control meal every day for 3 months, complete online surveys and cognitive testing before and after, and keep a record of the food they eat during the study.

Description:

The purpose of this study is to understand how a healthy diet is related to thinking ability and memory in people with MS. This study is fully remote consisting of meals being delivered to participant homes using Daily Harvest meal delivery service. Participants will be asked to consume a microwaveable study meal or prepackaged smoothie every day for 12 weeks. The study meals and smoothies will follow either a dietary pattern thought to improve brain health (MIND), or a control diet, and will include foods commonly found in grocery stores. Participants will not know which diet they are assigned to (active or control). Participants will also be asked to follow simple dietary guidance on a healthy diet in addition to the meals provided. Participants will complete a series of online forms or surveys. Additionally, participants will complete an online cognitive battery (CANTAB) at the beginning and end of the study.

Recruitment information / eligibility

• Status: Not yet recruiting
• Enrollment: 40
• Est. completion date: December 31, 2026
• Est. primary completion date: January 1, 2026
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 64 Years

Eligibility

Inclusion Criteria:

1. Individuals aged 18-64 years old

2. Self-reported diagnosis of Multiple sclerosis (MS)

3. 20/20 or corrected vision

4. No other neurodegenerative disease diagnosis

5. Stable disease-modifying therapy (DMT) within 6 months

6. Not Pregnant or lactating

7. No food allergies or intolerances

8. Able to consume study meals

9. Not enrolled in another dietary, exercise, or medication study during the study

10. Access to a computer/laptop with internet

Exclusion Criteria:

1. Individuals younger than 18 or older than 64 years old

2. No self-reported diagnosis of Multiple sclerosis (MS)

3. Not 20/20 or uncorrected vision

4. Other neurodegenerative disease diagnosis

5. Disease modifying therapy (DMT) less than 6 months

6. Pregnant or lactating

7. Food allergies or intolerances

8. Not able to consume study meals

9. Enrolled in another dietary, exercise, or medication study during the study

10. No access to a computer/laptop with internet

Related Conditions & MeSH terms

• Cognitive Change
• Multiple Sclerosis

Intervention

Other:
• MIND Diet
Daily meals designed to increase adherence to the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) dietary pattern.
• Control Diet
Daily meals designed to increase fruit, vegetable, and whole grain intake consistent with a healthy American diet.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of Illinois at Urbana-Champaign

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Information Processing	Rapid Visual Information Processing Task from CANTAB online battery	12 weeks (Baseline vs. Follow Up)
Primary	Visual Processing	Match to Sample Visual Search from CANTAB online battery	12 weeks (Baseline vs. Follow Up)
Primary	Processing Speed	Digit Span from CANTAB online battery	12 weeks (Baseline vs. Follow Up)
Primary	Learning	Paired Associates Learning Task from CANTAB online battery	12 weeks (Baseline vs. Follow Up)
Primary	Memory	Spatial Working Memory from CANTAB online battery	12 weeks (Baseline vs. Follow Up)
Secondary	MIND Scores	MIND dietary pattern scores calculated from diet records/surveys	12 weeks (Baseline vs. Follow Up)