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National, Multicentric Registry Study on Neuroimmunological Diseases in China — NIDBase  

Multiple Sclerosis Clinical Trial

Official title:
National, Multicentric Registry Study on Neuroimmunological Diseases in China

Clinical Trial Summary

The aim of this study is to establish a real-world clinical neuroimmune disease research cohort, to follow up and observe the prognosis of patients with different subtypes and subgroups, and to provide support for the treatment, early warning, and outcome prediction research of neuroimmune diseases.

Clinical Trial Description

The purposes of this study are:(1)Establishing a clinical neuroimmune disease research cohort.(2)Collecting the blood, cerebrospinal fluid and other biological samples of the enrolled patients to discover and detect the new neural antibodies, so as to facilitate the diagnosis of related diseases.(3) Conducting in-depth exploration of the Genetic material of patients with neuroimmune diseases and healthy volunteers with second-generation sequencing technology, discovering the pathogenic genes and the mechanism of disease progression.The enrolled patients will be collected Clinical and therapeutic information. Blood and cerebrospinal fluid from the patients will be collected for sequencing analysis and antibody detection. They will also receive the 2-year follow-up with collection of basic clinical information, cognitive function, EDSS score, etc. Healthy volunteers will have their blood collected for sequencing analysis. Finish the gene sequencing analysis of blood samples from enrolled patients and healthy volunteers to establish the disease gene database and the reference gene database of the healthy population and find the unique expression quantitative trait loci (eQTL) in China, so as to clarify the pathogenic genes and the key mechanism of neuroimmune disease occurrence and development. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06443333
Study type Observational [Patient Registry]
Source Xuanwu Hospital, Beijing
Contact Junwei Hao, MD
Phone 01083198277
Email haojunwei@vip.163.com
Status Recruiting
Phase
Start date December 1, 2020
Completion date December 30, 2024
View Details
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