ADAs to Alemtuzumab

Status Active, not recruiting

Clinical Trial Summary

The main aim is to quantify the changes in alemtuzumab antibody-anti-alemtuzumab over a 24 months period

Clinical Trial Description

Primary To quantify the longitudinal changes in alemtuzumab ADAs over a 24 month period. Secondary 1. Relative occurrence of infusion-related reactions based on high alemtuzumab ADA levels prior to course 2. 2. Relative change in lymphocyte counts after the second infusion of alemtuzumab in ADA positive patients to assess the health economic impact of infusion-related reactions. 3. Relative change in relapses or EDSS score based on alemtuzumab ADA levels to assess the health economic impact of disease activity. 4. Relative change in relapses or EDSS score based on alemtuzumab ADA levels. 5. Relative change in T2 lesion number or Gd-enhancing lesions, and serum NfL based on alemtuzumab ADA levels to assess the health economic impact of disease activity. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06310343
Study type	Observational
Source	Queen Mary University of London
Contact
Status	Active, not recruiting
Phase
Start date	April 25, 2022
Completion date	November 30, 2025

View Details

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