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Assessing the Role of Mitochondrial Dysfunction in Primary Progressive Multiple Sclerosis

Multiple Sclerosis Clinical Trial

Official title:
Assessing the Role of Mitochondrial Dysfunction in Primary Progressive Multiple Sclerosis

Clinical Trial Summary

The purpose of this project is to study genetic determinants of mitochondrial impairment in primary progressive multiple sclerosis. Specific aims are: 1) identify mitochondrial-related pathways, inherited and somatic mitochondrial DNA mutations associated to primary progressive multiple sclerosis, 2) functionally assess the identified genetic alterations.

Clinical Trial Description

Multiple Sclerosis is a major cause of neurological disability, with a high socio-economic impact that increases as disability progresses. Effective treatment of primary progressive multiple sclerosis is still an unmet need and the underlying neurodegenerative processes have to be fully investigated. The purpose of this project is to study genetic determinants of mitochondrial impairment in primary progressive multiple sclerosis. Altered mitochondrial pathways will be investigate, as well as inherited and tissue-specific somatic mitochondrial variations associated with primary progressive multiple sclerosis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06025903
Study type Observational
Source IRCCS San Raffaele
Contact Federica Esposito
Phone 0226437833
Email esposito.federica@hsr.it
Status Recruiting
Phase
Start date September 20, 2021
Completion date May 30, 2025
View Details
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