Effect of Life Kinetik Training on Lower Limb Coordination in Ataxic Patients

Multiple Sclerosis Clinical Trial

Official title:

Effect of Life Kinetik Training on Lower Limb Coordination in Ataxic Patients

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT06001424
• Other study ID #: P.T.REC/012/001987
• Status: Completed
• Phase: N/A
• Start date: June 24, 2018
• Est. completion date: May 29, 2021

Study information

• Verified date: August 2023
• Source: Cairo University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Coordination is essential for the performance of most daily motor activities. Coordination problems are common in MS patients. One of the most commonly reported symptoms is dysmetria (limb ataxia). Ataxia is thought to occur in about 80% of MS patients. It leads to limitations in daily life activities. Aim of Study: to investigate the effect of life kinetik training on lower limb coordination in MS patients with ataxia.

Description:

Methods: Thirty remitting relapsing Multiple Sclerosis (RRMS) patients from both sexes with ataxic symptoms, will be recruited from multiple sclerosis specialized clinic in the Neurology department, Faculty of Medicine, Cairo University with EDSS score will be ranged from 2 to 4 and SARA score will be ranged from 1 to 10. Lower Extremity Motor Coordination Test (LEMOCOT) will be used to assess lower limb motor coordination. They will be randomly assigned into two equal groups; control group (GI) will receive selected physical therapy program and study group (GII) will receive same program of (GI) in addition to life kinetik training.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 30
• Est. completion date: May 29, 2021
• Est. primary completion date: April 30, 2021
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 45 Years

Eligibility

Inclusion Criteria:

• MS from both sexes
• Patients' age will be ranged from 20 to 45 years
• Expanded disability scale (EDSS) score ranging from "two" to "four"

Exclusion Criteria:

• Patients with Ataxia caused by other cause rather than MS
• Patients with other neurological disease or orthopedic deformities may affect movement
• Patients with cardiovascular and pulmonary diseases that make exercise unsafe
• Patients with cognitive impairment or psychiatric disorders

Related Conditions & MeSH terms

• Ataxia
• Multiple Sclerosis
• Sclerosis

Intervention

Other:
• physical therapy
Frenkel's exercises for lower limb, Proprioceptive neuromuscular facilitation for upper limb in the form of rhythmic stabilization
• life kinetic exercises
A multimodal training that combines coordinative, cognitive and visual tasks.

Locations

Country	Name	City	State
Egypt	Faculty of Physical Therapy	Giza

Sponsors (1)

Lead Sponsor	Collaborator
Cairo University

Country where clinical trial is conducted

Egypt, 

References & Publications (1)

Edwards EM, Fritz NE, Therrien AS. Cerebellar Dysfunction in Multiple Sclerosis: Considerations for Research and Rehabilitation Therapy. Neurorehabil Neural Repair. 2022 Feb;36(2):103-106. doi: 10.1177/15459683211065442. Epub 2021 Dec 21. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Lower Extremity Motor Coordination Test (LEMOCOT)	test to assess lower limb coordination	at baseline
Primary	Lower Extremity Motor Coordination Test (LEMOCOT)	test to assess lower limb coordination	post intervention (after one month)
Secondary	Four Square Step Test (FSST)	test to assess dynamic balance	at baseline
Secondary	Four Square Step Test (FSST)	test to assess dynamic balance	post intervention (after one month)