TENS in Persons With MS

Multiple Sclerosis Clinical Trial

Official title: Transcutaneous Electrical Nerve Stimulation in Persons With MS

Status Recruiting

Clinical Trial Summary

Persons with multiple sclerosis (pwMS) often have an increased sense of fatigue. Furthermore, they present walking difficulties which negatively affects their mobility and results in an additional increase of fatigue. Previous literature suggests that transcutaneous electrical nerve stimulation (TENS) of leg muscles might increase their walking capacity and decrease perception of fatigue. In the present study we aim to investigate whether TENS of leg muscles reduces walking difficulties and sense of fatigue in pwMS in comparison with a short strength training protocol or no training. A similar aim is addressed after TENS of elbow flexor muscles.

Subjects with relapsing remitting or progressive MS, age between 18 and 65 years, will undergo transcutaneous electrical nerve stimulation (TENS), strength exercises (SExerc), both TENS and SExerc (COMB) simultaneously, or sham stimulation without training (CON) of both leg and arm muscles. Force and fatigue measurements are performed before, directly after and three weeks after the training sessions and contain walking, fatigue, and strength assessments.

Main study parameters are changes in the scores of i) the six-minute walking test (6-MWT), ii) the perceived walking disability (MSWS-12) and iii) fatigue questionnaires (FSS and MFIS). Additional study parameters are changes in muscle force and muscle fatigability.

Clinical Trial Description

n/a

Related Conditions & MeSH terms

• Multiple Sclerosis

• NCT number: NCT05321927
• Study type: Interventional
• Source: University Medical Center Groningen
• Contact: Inge CAT Zijdewind, PhD
• Phone: +31 50 361 6438
• Email: c.a.t.zijdewind@umcg.nl
• Status: Recruiting
• Phase: N/A
• Start date: January 5, 2022
• Completion date: December 31, 2023