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NCT05196425 Clinical Trial

Expression of PARP-1 in Multiple Sclerosis Patients

Multiple Sclerosis Clinical Trial

Official title:
Expression of PARP-1 in Optic Neuritis of Multiple Sclerosis Patients

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05196425
Other study ID # Soh-Med-21-05-12
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date August 1, 2021
Est. completion date April 2022

Study information
Verified date January 2022
Source Sohag University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

This study will explore the expression of PARP-1 in optic neuritis of multiple sclerosis patients. The data will be collected from Sohag University hospital in the period from the start of August 2021 to the end of December 2021. The study protocol will be approved by the Scientific Research Ethical Committee, Faculty of Medicine, Sohag University.

Recruitment information / eligibility
Status Recruiting
Enrollment 80
Est. completion date April 2022
Est. primary completion date March 2022
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 20 Years to 45 Years
Eligibility Inclusion Criteria: - Patients with multiple sclerosis with or without optic neuritis Multiple sclerosis will be diagnosed according to the McDonald criteria Exclusion Criteria: - • Isolated optic neuritis.

Study Design

Related Conditions & MeSH terms

Intervention

Genetic:
• Blood sampling
Blood sample for detection of PARP-1 gene and correlate to changes of the optic disc, RNFL and GCC layers of the retina of MS patients

Locations
Country Name City State
Egypt Elshimaa A.Mateen Sohag

Sponsors (1)
Lead Sponsor Collaborator
Sohag University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary measure PARP-1 mRNA measure PARP-1 mRNA 2 weeks
Secondary Optic nerve, RNFL and GCC layer affection by MS Optic nerve Retinal nerve fibre layer (RNFL) in um
) and Ganglion cell complex (GCC) layer affection in um by MS in correlation to PARP-1 mRNA		 2 weeks
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