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NCT04792866 Clinical Trial

3D FLAIR Versus Coronal T2-WI MRI in Detecting Optic Neuritis (FLACON)

Multiple Sclerosis Clinical Trial

— FLACON  

Official title:
3D FLAIR Versus Coronal T2-WI MRI in Detecting Optic Neuritis in Patients Presenting With Acute Visual Loss and Otherwise Normal Ophthalmological Examination

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT04792866
Other study ID # CE_20200204_1_ALR
Secondary ID
Status Completed
Phase
First received
Last updated
Start date January 1, 2018
Est. completion date August 1, 2020

Study information
Verified date March 2021
Source Fondation Ophtalmologique Adolphe de Rothschild
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

3D FLAIR, 3D T1 FAT SAT, coronal T2 and coronal T1 dixon sequences were usually used to assess visual deficits in MRI. Optic nerve examination is preferably performed using a coronal T2 sequence in order to detect a hypersignal suggestive of inflammation whereas brain examination is preferably performed using a 3D FLAIR sequence to highlight signs of spatial dissemination and lesions suggestive of multiple slerosis (MS). Recently, a study based on a small number of patients showed the interest of 3D FLAIR in the detection of the hypersignal of the optic nerve.The objective of this retrospective study is to determine whether a single 3D FLAIR sequence allows simultaneous exploration of the optic nerve and the brain for the positive diagnosis of optic neuropathy and/or MS.

Recruitment information / eligibility
Status Completed
Enrollment 1200
Est. completion date August 1, 2020
Est. primary completion date March 1, 2020
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - Age > 18 years - Decrease in visual acuity explored in MRI between january 2018 and january 2020 Exclusion Criteria: - Past history of episode of Optic neuritis

Study Design

Related Conditions & MeSH terms

Intervention

Diagnostic Test:
• Magnetic Resonance Imaging
Comparing 3D FLAIR versus Coronal T2-WI MRI in detecting Optic Neuritis

Locations
Country Name City State
France Hôpital Fondation Adolphe de Rothschild Paris Ile-de-France

Sponsors (1)
Lead Sponsor Collaborator
Fondation Ophtalmologique Adolphe de Rothschild

Country where clinical trial is conducted

France, 

Outcome
Type Measure Description Time frame Safety issue
Primary Detection of optic neuropathies using MRI MRI comparison of the diagnostic performance of the 3D FLAIR sequence and the T2 coronal in the detection of optic neuropathies. 1 hour
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