Multiple Sclerosis Clinical Trial
Official title:
Reducing Symptoms of Multiple Sclerosis Using Non-invasive Neuromodulation
This study sought to examine the effect of targeted physical therapy with and without cranial nerve non-invasive neuromodulation (CN-NINM), on the walking ability of people with MS who exhibited a dysfunctional gait.
Background: This study sought to examine the effect of targeted physical therapy with and
without cranial nerve non-invasive neuromodulation (CN-NINM), on the walking ability of
people with MS who exhibited a dysfunctional gait. The investigators hypothesized that
subjects who received electrical stimulation would have greater improvement than those who
had a control device after a 14-week intervention. Gait disturbance is a common problem for
people with multiple sclerosis (MS). The investigators have developed an effective
rehabilitative strategy using neuromodulation of the cranial nerves via electrical
stimulation of the tongue to enhance the plasticity of the brain.
Methods: The study is a within-subject blinded randomized control design. Twenty chronic MS
subjects with an identified gait disturbance were assigned to either an active or control
group. Both groups completed a 14-week intervention program using a standardized combination
of exercise and a device that provided electrical stimulation to the tongue. Those in the
active group received electrical stimulation on the tongue that they could perceive. Those in
the control group used a device that did not provide a physiologically significant stimulus
and was not perceivable. Subjects were assessed with the Dynamic Gait Index (DGI).
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