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NCT04210960 Clinical Trial

Correlation of Serum Lactate and Activity of Multiple Sclerosis

Multiple Sclerosis Clinical Trial

Official title:
Correlation of Serum Lactate and Activity of Multiple Sclerosis

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT04210960
Other study ID # Mansoura University H 10
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date December 23, 2019
Est. completion date June 1, 2020

Study information
Verified date December 2019
Source Mansoura University Hospital
Contact Esmael M Ahmed, MD
Phone 00201000372787
Email deltaneuro@yahoo.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Correlation of serum lactate and activity of multiple sclerosis and its correlation to different type of MS

Description:

Correlation of serum lactate and activity of multiple sclerosis and its correlation to different type of MS and magentic resonanace imaging , magentic resonanace spectroscopy

Recruitment information / eligibility
Status Recruiting
Enrollment 80
Est. completion date June 1, 2020
Est. primary completion date May 1, 2020
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 20 Years and older
Eligibility Inclusion Criteria:

-Patients with multiple sclerosis (RRMS,PPMS and SPMS)

Exclusion Criteria:

-Patients with any other medical conditions that may affect the serum lactate level

Study Design

Related Conditions & MeSH terms

Intervention

Radiation:
• Magentic resonanace imaging
The brain MR imaging examinations were done by using a 3 tesla scanner (Acheiva; Philips Medical Systems, Best, Netherlands). All patients were examined in the supine position using head coil. Routine images (T2, T1, FLAIR) and double inversion recovery sequence (DIR) were done to all patients: repetition time (TR) _ 9583 sec, echo time (TE) _ 25 sec, inversion time (TI) _ 3400 sec, IR delay _ 325 sec, echo train length (ETL) _ 17, 50 contiguous axial slices, thickness _ 3 mm, matrix size 240× 142 mm2, field of view (FOV) 230× 184 mm2.
• Magentic resonanace spectroscopy
Magnetic Resonance (MR) spectroscopy is a noninvasive diagnostic test for measuring biochemical changes in the brain.While magnetic resonance imaging (MRI) identifies the anatomical location of a lesion, MR spectroscopy compares the chemical composition of normal brain tissue with abnormal brain tissue. This test can also be used to detect tissue changes in stroke and epilepsy.

Locations
Country Name City State
Egypt Mansoura University Hospital Mansoura Dakahlia

Sponsors (1)
Lead Sponsor Collaborator
Mansoura University Hospital

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary Biochemical testing Plasma lactate was assayed according to Trinder method14 . All assays were carried out with Bechman Coulter AU480 autoanalyzer (USA). 2 days
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