Acute Effects of Whole-body Vibration Training in Hypoxia and Normoxia in Multiple Sclerosis Patients

Multiple Sclerosis Clinical Trial

Official title:

Acute Effects of Whole-body Vibration Training in Hypoxia and Normoxia Condition on Neuromuscular Performance and Mobility in Patients With Multiple Sclerosis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03856801
• Other study ID #: CE061908
• Status: Completed
• Phase: N/A
• Start date: June 15, 2018
• Est. completion date: August 30, 2018

Study information

• Verified date: February 2019
• Source: Universidad Católica San Antonio de Murcia
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Multiple Sclerosis (ME) is a degenerative, inflammatory and autoimmune demyelinating disease of the central nervous system, characterized by demyelination due to inflammation and degeneration of the myelin sheaths enveloping nerves of the eye, periventricular grey matter, brain, spinal cord and brainstem. The symptoms associated with MS include symptomatic fatigue, muscle weakness, ataxia, mobility and balance problems or cognitive problems. Moderate intensity strength training has been shown to improve strength and mobility in persons with MS. It was suggested that whole-body vibration training (WBVT) is effective to improve muscle strength, such as resistance training, resulting from both neural and structural adaptations. On the other hand, traditional strength training in hypoxia has garnered much attention. This method has shown improvements in isometric strength and increases in muscle size.

Description:

• Crossover.

• 13 patients with multiple sclerosis were recruited.

• Patients performed two sessions: whole-body vibration training in normoxia condition and whole-body vibration in hypoxia condition.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 13
• Est. completion date: August 30, 2018
• Est. primary completion date: July 30, 2018
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• mild or moderate disability with clinical mild spastic-ataxic gait disorder.

• stable phase of the disease.

Exclusion Criteria:

• Expanded Disability Status Scale (EDSS) < 6.

• relapsing disease within the preceding 12 months.

• corticosteroid treatment within the last months before study inclusion.

Related Conditions & MeSH terms

• Hypoxia
• Multiple Sclerosis
• Sclerosis

Intervention

Other:
• Exercise
Whole-body vibration training in hypoxia and normoxia condition

Locations

Country	Name	City	State
Spain	Universidad Católica San Antonio	Murcia

Sponsors (1)

Lead Sponsor	Collaborator
Universidad Católica San Antonio de Murcia

Country where clinical trial is conducted

Spain, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Maximal Voluntary Isometric Contraction of Knee Extension		Immediately before the training sessions
Primary	Maximal Voluntary Isometric Contraction of Knee Extension		Immediately after the training sessions
Primary	Rate of Force Development		Immediately before the training sessions
Primary	Rate of Force Development		Immediately after the training sessions
Primary	Central Activation Ratio		Immediately before the training sessions
Primary	Central Activation Ratio		Immediately after the training sessions
Primary	Biomechanical study of the walk by video recording	Kinematic analysis of knee and ankle angles during walking	Immediately before the training sessions
Primary	Biomechanical study of the walk by video recording	Kinematic analysis of knee and ankle angles during walking	Immediately after the training sessions
Primary	Biomechanical study of the walk by video recording	Stride amplitude during walking	Immediately before the training sessions
Primary	Biomechanical study of the walk by video recording	Stride amplitude during walking	Immediately after the training sessions
Primary	Spasticity	Pendulum test	Immediately before the training sessions
Primary	Spasticity	Pendulum test	Immediately after the training sessions
Secondary	Rate of Perceived Exertion	RPE Scale 6-20	Immediately before the training sessions
Secondary	Rate of Perceived Exertion	RPE Scale 6-20	Immediately after the training sessions
Secondary	Walking speed	Test 10 m-walks	Immediately before the training sessions
Secondary	Walking speed	Test 10 m-walks	Immediately after the training sessions
Secondary	Static balance	Romberg Test with eyes open and closed. Analysis with force plates	Immediately before the training sessions
Secondary	Static balance	Romberg Test with eyes open and closed. Analysis with force plates	Immediately after the training sessions
Secondary	Muscle oxygenation in soleus	MOXY's	Immediately before the training sessions
Secondary	Muscle oxygenation in soleus	MOXY's	Immediately after the training sessions