Multiple Sclerosis Clinical Trial
Official title:
Phenotypic and Functional Study of 4BL B Cells in Multiple Sclerosis (MS)
Recent works highlight the B cells involvement in multiple sclerosis (MS) pathology but their
role remains poorly understood. It was previously described that activated memory B cells
called 4BL due to the increased expression of 4-1BBL, an activation marker, induce
pro-inflammatory response by activating T CD8+ lymphocytes. Those 4BL cells are also
described in systemic inflammation in 80 years old people explaining the poor efficiency of
vaccination in that sub population. Those 4BL cells can also induce anti-tumoral T cell
response.
The hypothesize is that 4BL may induce a pathogenic inflammatory response in MS.
the aim to compare the proportion of peripheral (blood) 4 BL cells but also 4-BL cells in
cerebro spinal fluid (CSF) in MS compared to healthy controls and to other inflammatory
neurological disease but also non inflammatory neurological disease.
For all groups of patients and controls it will collect blood and CSF only once (at diagnosis
time for patients).
Blood collect from healthy controls will come from transfusion volunteers and we won't have
CSF from them.
For patients from the MS group, the blood collect will be sequential at diagnosis, 3, 6, 12
and 24 months after during the follow up.
In the blood and CSF we will evaluate:
- percentage of 4 BL cells. 4 BL cells are found using cytometric parameters
- capacity of 4 BL cells to induce inflammatory response in vitro: percentage of induced
activated TCD8 proliferation after cell culture using extracellular and intracellular
cytometric parameters
;
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT05528666 -
Risk Perception in Multiple Sclerosis
|
||
| Completed |
NCT03608527 -
Adaptive Plasticity Following Rehabilitation in Multiple Sclerosis
|
N/A | |
| Recruiting |
NCT05532943 -
Evaluate the Safety and Efficacy of Allogeneic Umbilical Cord Mesenchymal Stem Cells in Patients With Multiple Sclerosis
|
Phase 1/Phase 2 | |
| Completed |
NCT02486640 -
Evaluation of Potential Predictors of Adherence by Investigating a Representative Cohort of Multiple Sclerosis (MS) Patients in Germany Treated With Betaferon
|
||
| Completed |
NCT01324232 -
Safety and Efficacy of AVP-923 in the Treatment of Central Neuropathic Pain in Multiple Sclerosis
|
Phase 2 | |
| Completed |
NCT04546698 -
5-HT7 Receptor Implication in Inflammatory Mechanisms in Multiple Sclerosis
|
||
| Active, not recruiting |
NCT04380220 -
Coagulation/Complement Activation and Cerebral Hypoperfusion in Relapsing-remitting Multiple Sclerosis
|
||
| Completed |
NCT02835677 -
Integrating Caregiver Support Into MS Care
|
N/A | |
| Completed |
NCT03686826 -
Feasibility and Reliability of Multimodal Evoked Potentials
|
||
| Recruiting |
NCT05964829 -
Impact of the Cionic Neural Sleeve on Mobility in Multiple Sclerosis
|
N/A | |
| Withdrawn |
NCT06021561 -
Orofacial Pain in Multiple Sclerosis
|
||
| Completed |
NCT03653585 -
Cortical Lesions in Patients With Multiple Sclerosis
|
||
| Recruiting |
NCT04798651 -
Pathogenicity of B and CD4 T Cell Subsets in Multiple Sclerosis
|
N/A | |
| Active, not recruiting |
NCT05054140 -
Study to Evaluate Efficacy, Safety, and Tolerability of IMU-838 in Patients With Progressive Multiple Sclerosis
|
Phase 2 | |
| Completed |
NCT05447143 -
Effect of Home Exercise Program on Various Parameters in Patients With Multiple Sclerosis
|
N/A | |
| Recruiting |
NCT06195644 -
Effect of Galvanic Vestibular Stimulation on Cortical Excitability and Hand Dexterity in Multiple Sclerosis Patients
|
Phase 1 | |
| Completed |
NCT04147052 -
iSLEEPms: An Internet-Delivered Intervention for Sleep Disturbance in Multiple Sclerosis
|
N/A | |
| Completed |
NCT03594357 -
Cognitive Functions in Patients With Multiple Sclerosis
|
||
| Completed |
NCT03591809 -
Combined Exercise Training in Patients With Multiple Sclerosis
|
N/A | |
| Completed |
NCT03269175 -
BENEFIT 15 Long-term Follow-up Study of the BENEFIT and BENEFIT Follow-up Studies
|
Phase 4 |