Muscle Architecture of Lower Extremity In Multiple Sclerosis

Multiple Sclerosis Clinical Trial

Official title:

Muscle Architecture of Lower Extremity In Multiple Sclerosis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03766698
• Other study ID #: SankoUniversity
• Status: Completed
• Start date: December 18, 2018
• Est. completion date: February 15, 2020

Study information

• Verified date: March 2020
• Source: Sanko University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational [Patient Registry]

Clinical Trial Summary

The aim of this study was to determine the muscle architecture of the lower extremity muscles (pennation angle, muscle fiber length and muscle thickness) in patients with multiple sclerosis. Lower extremity muscles of patients with multiple sclerosis and healthy individuals; rectus femoris, biceps femoris, tibialis anterior, gastrosoleus and gastrocnemius muscles will be examined by ultrasound method.

Description:

Multiple sclerosis (MS) is characterised by complex and heterogeneous symptoms, often leading to reduced quality of life and impaired functional capacity. The latter is related to reduced muscle strength of predominately the lower limbs . The mechanisms underlying the observed strength deficits are of muscular as well as neural origin . At the whole muscle level, a number of studies have examined skeletal muscle characteristics of MS patients, with some studies but not all, reporting loss of muscle mass and decreased or comparable maximal muscle strength.

However, there is no study describing the features of lower extremity muscle architecture in multiple sclerosis. Muscle architecture is defined as the alignment of muscle fibers with respect to the axis of force. Although the diameters of the muscles of different sizes are quite similar to the diameters of the fibers, the sequences of these fibers contain several differences. The alignment of the muscle forming fibers has a significant effect on the force of muscle formation. The parameters that determine muscle architecture characteristics are the muscle fiber length, pennation angle, the physiological cross-sectional area. For each muscle these parameters may differ from each other. Any type of load in the case is the result of an adaptation process that results in muscle development. Muscle architecture allows the macroscopic understanding and interpretation of this adaptation process.

Determining the muscle architecture of multiple sclerosis patients by ultrasound will guide the rehabilitation process.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 35
• Est. completion date: February 15, 2020
• Est. primary completion date: January 18, 2020
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 50 Years

Eligibility

Inclusion Criteria:

• 18-50 years old

• Individuals who agree to be voluntary,

• With the EDSS 4 and below

• Without pregnancy

• Do not receive corticosteroid treatment in the last month

• Do not take any medicine that will affect walking in the last 1 month

Exclusion Criteria:

• Those who refuse to volunteer,

• EDSS over 4

• Pregnancy

• Corticosteroid therapy within 1 month

• Any medication that will affect walking in the last 1 month

Related Conditions & MeSH terms

• Multiple Sclerosis
• Sclerosis

Locations

Country	Name	City	State
Turkey	Sanko University	Gaziantep

Sponsors (1)

Lead Sponsor	Collaborator
Sanko University

Country where clinical trial is conducted

Turkey, 

References & Publications (1)

Wens I, Dalgas U, Vandenabeele F, Krekels M, Grevendonk L, Eijnde BO. Multiple sclerosis affects skeletal muscle characteristics. PLoS One. 2014 Sep 29;9(9):e108158. doi: 10.1371/journal.pone.0108158. eCollection 2014. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Thickness of subcutaneous fat from anterior thigh	Subcutaneous fat will be assesed with skinfold from anterior thigh. At the same time the thickness of subcutaneous fat will also be evaluated by ultrasound imaging.	The evaluation will be made on the first 1 day.
Other	Thickness of subcutaneous fat from posterior leg	Subcutaneous fat will be assesed with skinfold from posterior leg. At the same time the thickness of subcutaneous fat will also be evaluated by ultrasound imaging.	The evaluation will be made on the first 1 day.
Primary	Muscle Architecture Pennation Angle	Pennation Angle will be assesed by ultrasound imaging.	The evaluation will be made on the first 1 day.
Primary	Muscle Architecture Muscle Fiber Lengh	Muscle Fiber Lenght will be assesed by ultrasound imaging.	The evaluation will be made on the first 1 day.
Primary	Muscle Architecture Muscle Thickness	Muscle Thickness will be assesed by ultrasound imaging.	The evaluation will be made on the first 1 day.
Secondary	Muscle Strength	Ouadriceps, Hamstring, Gastrosoleus and Gastrocnemius muscle Strenght will be asses with digital hand-held dynamometer (Commander PowerTrack II muscle tester).	The evaluation will be made on the first 1 day.
Secondary	Circumference Measurement of Thigh	Thigh circumference will be measured with a tape measure. Thigh circumference measurement will be measured from the midline of the inguinal line and superior patella.	The evaluation will be made on the first 1 day.
Secondary	Circumference Measurement of shin	Shin circumference will be measured with a tape measure.Shin circumference measurement will be measured from the poplital line and the middle point of the achilles.	The evaluation will be made on the first 1 day.

External Links

•   Multiple Sclerosis and Skeletal Muscle