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Impact of Ketone Bodies and Epigallocatechin Gallate in Multiple Sclerosis

Multiple Sclerosis Clinical Trial

Official title:
Impact of Ketone Bodies and Epigallocatechin Gallate in Multiple Sclerosis

Clinical Trial Summary

Based on the fact that the fundamental pathogenic mechanism of the Multiple Sclerosis (MS) disease is neuroinflammation, related in turn to cellular oxidation and mitochondrial alterations, this project aims to assess the impact of a nutritional intervention on the evolution of MS patients in their different slopes. To this end, the administration of medium-chain triglycerides, whose metabolism produces the increase of ketone bodies in the blood, will be carried out; and another of the antioxidant polyphenol epigallocatechin gallate. This procedure will be applied over 6 months, based on a isocaloric Mediterranean diet, with a population for the study of 80 patients with different variants of the disease. The assessment of the intervention will be carried out every two months, at motor-functional, anthropometric, cognitive and emotional, inflammatory, and oxidation levels.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03740295
Study type Interventional
Source Fundación Universidad Católica de Valencia San Vicente Mártir
Contact
Status Completed
Phase Phase 2
Start date October 5, 2018
Completion date February 5, 2019
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