Neurofilaments for NEDA Assessing in MS

Status Terminated

Clinical Trial Summary

Goal is to evaluate the achievement of biological NEDA as demonstrated by a drop in neurofilament levels in MS patients commencing Alemtuzumab therapy as part of their MS management.

Clinical Trial Description

Primary 1. To evaluate the achievement of NEDA using blood and CSF neurofilaments in Alemtuzumab treated patients. Secondary 2. To assess prognosis at the end of the study based on neurofilament status. 3. To correlate neurofilament levels with clinical and MRI markers of disease activity. 4. To evaluate the effect of Alemtuzumab on the profile of other CSF, blood, urine, faeces biomarkers of inflammation, neurodegeneration, neuronal sprouting and synaptogenesis, treatment activity and metabolic activity. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT03250169
Study type	Observational
Source	Queen Mary University of London
Contact
Status	Terminated
Phase
Start date	August 1, 2017
Completion date	January 28, 2022

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