Multiple Sclerosis Clinical Trial
Official title:
A Double-Blind, Placebo-Controlled, Crossover Study to Evaluate the Safety and Efficacy of ABX-1431 in Patients With Central Pain
This study will determine the safety and tolerability of ABX-1431 in patients with central
pain when added on to background pain therapy.
During the course of this study, each participant will take a daily dose of 20 mg of ABX-1431
or a matching placebo for approximately 7 to 9 weeks.
This is a double-blind, placebo-controlled crossover study, randomized, crossover study of
ABX-1431 HCl as add-on therapy in the treatment of central neuropathic pain.The efficacy of
ABX-1431 will also be assessed by the change in pain intensity scores using a numerical
rating scale (NRS-11).
All patients will undergo a screening visit for enrollment criteria. Eligible patients will
be treated with daily medication for 7 to 9 weeks, which will include some treatment with
placebo and some treatment with ABX-1431 HCl. Patients will use a web based application to
record their daily average pain using a numerical rating scale (NRS-11).
This study will enroll up to 32 patients with chronic central pain due to one of the four
following diagnostic groups: Neuromyeliltis Optica Spectrum Disorder (NMOSD), longitudinally
extensive transverse myelitis (LETM), Multiple Sclerosis (MS), and Transverse Myelitis (TM).
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