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NCT03108573 Clinical Trial

Improved Detection of Multiple Sclerosis Plaques in Inversion Recovery by Optimization of Sequence Parameters

Multiple Sclerosis Clinical Trial

— FLAIR-SEP  

Official title:
Improved Detection of Multiple Sclerosis Plaques in Inversion Recovery by Optimization of Sequence Parameters

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT03108573
Other study ID # SC/DM_JSY_2012-3
Secondary ID
Status Completed
Phase N/A
First received March 16, 2017
Last updated April 5, 2017
Start date December 12, 2012
Est. completion date July 31, 2013

Study information
Verified date March 2017
Source Fondation Ophtalmologique Adolphe de Rothschild
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

This study evaluates different optimized MRI sequences for the detection of brain lesions in patients with multiple sclerosis in comparison with the recommended FLAIR sequence

Description:

MRI is a tool of choice for detecting demyelinating lesions in Multiple Sclerosis (MS) disease. On a consensual basis, the detection of those lesions in done on FLAIR (FLuid Attenuated Inversion Recovery) sequences, weighted T2 with cancelling of fluid signal, leading to a much better contrast between the lesion and the environment. The environment is displayed as a iso-signal for the surrounding healthy brain's white matter and as a hypo-signal for the fluids. Keys parameters indicative of the sequence's contrast are the echo time, the reversal time, and the repetition time, wich seems to be crucial to detect the lesions, according to relatively discordant results of publications using different technologies of FLAIR. Although 3D FLAIR sequences play an essential role for diagnosis and evaluation (evolution under treatment, prognosis) of demyelinating pathologies there is no consensus on parameters used on routine basis.

The aim of the trial is to discover the optimal combination of theses parameters so as to well detect the lesions.

Recruitment information / eligibility
Status Completed
Enrollment 27
Est. completion date July 31, 2013
Est. primary completion date July 31, 2013
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria:

- relapsing remitting multiple sclerosis

- MRI required

Exclusion Criteria:

- MRI contraindication

Study Design

Related Conditions & MeSH terms

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Fondation Ophtalmologique Adolphe de Rothschild

Outcome
Type Measure Description Time frame Safety issue
Primary Number of detectable lesions quantification of lesions on each sequence baseline
Secondary localisation of lesions proportion of lesions localised in cerebellum or brainstem, on each sequence baseline
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