Multiple Sclerosis Clinical Trial
Official title:
Intensity Dependent Clinical Effects of a Task-oriented Upper Limb Training in Multiple Sclerosis
An adequate upper limb function is crucial to independently perform Activities of Daily
Living (ADL). Persons with neurological diseases often experience upper limb dysfunction.
Upper limb function in Multiple Sclerosis (MS) is highly prevalent, increasing with overall
disability level, while the detrimental impact on ADL is higher than in stroke, given that
symptoms often occur bilaterally. In contrast to stroke, it is unknown whether similar
rehabilitation principles and effect sizes apply in MS given that this progressive
neurodegenerative disease is characterized by multiple lesions and atrophy of brain
structures. To date, optimal therapy dosage of upper limb rehabilitation programs are not
known in the MS literature neither were characteristics of responders identified.
The aim of this explorative study is to investigate the intensity dependent clinical effects
of a task-oriented upper limb training in persons with MS with different upper limb
disability levels.
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