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Pharmacokinetics of DMF and the Effects of DMF on Exploratory Biomarkers

Multiple Sclerosis Clinical Trial

Official title:
An Open Label Study of the Pharmacokinetics of DMF and the Effects of DMF on Exploratory Biomarkers in Subjects With Secondary Progressive Multiple Sclerosis

Clinical Trial Summary

The purpose of this study is to explore whether DMF (Dimethyl Fumarate) or MMF (monomethyl fumarate) its main bioactive metabolite, is capable of entering the central nervous system in SPMS patients that are being treated with Tecfidera®. PK samples (pharmacokinetics - or the amount of study drug in blood) will be tested to compare with PK samples, the amount of study drug, in spinal fluid (CSF).

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT02683863
Study type Interventional
Source Multiple Sclerosis Center of Northeastern New York
Contact
Status Completed
Phase Phase 4
Start date August 2015
Completion date January 31, 2017
View Details
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