Multiple Sclerosis Clinical Trial
Official title:
Treating Anorectal Dysfunction Associated With Multiple Sclerosis
The investigators seek to test whether incorporating the scheduled dosing of a bisacodyl 10 mg rectal suppository every other day improves bowel-related symptoms in patients with multiple sclerosis. Patients will be randomized to receive either a placebo suppository or bisacodyl suppository dosed every other day for 4 weeks.
The majority of patients with multiple sclerosis (MS) suffer from some form of anorectal
dysfunction, and these difficulties with bowel function are often ranked as negatively
impactful on quality of life as impaired mobility. Despite the significant clinical burden of
these symptoms, there remains a paucity of published literature supporting specific
therapeutic options to manage anorectal dysfunction in this clinical population. Most bowel
regimens rely on either oral laxatives (i.e. PEG-3350) or anti-diarrheal agents (i.e.
loperamide). In their study, the investigators propose to establish the efficacy of a bowel
regimen that combines both oral agents (as needed; standard care) with scheduled, every other
day dosing of a placebo or stimulant laxative rectal suppository -- bisacodyl 10 mg.
Bisacodyl is a stimulant laxative medication that is available over-the-counter. It works by
activating nerves in the rectum to elicit rectal contractions which ultimately leading to
defecation.
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