Multiple Sclerosis Clinical Trial
Official title:
Cognitive Motor Interference During Dual Tasking With Movements of the Upper Limb in Persons With Multiple Sclerosis
Multiple sclerosis (MS) is a chronic, inflammatory, neurodegenerative disorder of the
central nervous system, with more than 2.5 million people in the world. It is the most
non-traumatic cause of disability in young and middle-aged adults.
Because the lesions are spread in the brains, there is a variety of symptoms. The most
common symptom is the typical motor dysfunction. 66% of persons with MS, and even 81% of
them after 15 years, have problems with movements in one or both upper extremities.
Also, 40 untill 70% of persons with Multiple Sclerosis have cognitive impairment. Although
they are less visible, they can have a major determining influence on social or work-related
domains. The most frequent cognitive dysfunctions are sustained attention, reduced speed of
information processing, impaired memory and limited executive functions.
When a combination, of motor and cognitive task, is asked, the execution of these tasks
could be difficult with the foregoing in mind. For example problems during chatting while
cooking, typing a report at a meeting or watching television while ironing.
The dual-task paradigm assumes that the attention should be divided between two simultaneous
tasks. A dual task cost (DTC) is a restriction in performance on each task, compared whit
the separate task versus simultaneously.
Research on dual tasking with persons with MS has already studied extensively, but not
specific on the upper limb. In 2015 Learmonth, Pilutti and Motl published an primary
research on the DTC. They combined the movements of the upper limb with a cognitive task.
The research showed a difference between Persons with MS and the control group. At
methodological level, there is lacking on the randomization of tasks. That is an important
bias because of the learning effect of the tasks. They used only one task for the upper
limb; this isn't enough to generalize the concept of motor interference in Persons with MS.
The study has two research questions:
- Have Persons with MS a greater DTC compared with a healthy control group? The motor
task is executed with the upper limb.
- Is there a difference on DTC in persons with MS depending on the motor task?
This research is an observational case-control study in which individuals with MS will be
compared to a healthy control group. They will be two moments of assessments. On the first
day the general performance of the persons will be measured, by using clinical evaluation
tests and questionnaires. On the second day they will be tests on the dual tasks, specific a
comparison between single versus simultaneously performed tasks.
n/a
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT05528666 -
Risk Perception in Multiple Sclerosis
|
||
Completed |
NCT03608527 -
Adaptive Plasticity Following Rehabilitation in Multiple Sclerosis
|
N/A | |
Recruiting |
NCT05532943 -
Evaluate the Safety and Efficacy of Allogeneic Umbilical Cord Mesenchymal Stem Cells in Patients With Multiple Sclerosis
|
Phase 1/Phase 2 | |
Completed |
NCT02486640 -
Evaluation of Potential Predictors of Adherence by Investigating a Representative Cohort of Multiple Sclerosis (MS) Patients in Germany Treated With Betaferon
|
||
Completed |
NCT01324232 -
Safety and Efficacy of AVP-923 in the Treatment of Central Neuropathic Pain in Multiple Sclerosis
|
Phase 2 | |
Completed |
NCT04546698 -
5-HT7 Receptor Implication in Inflammatory Mechanisms in Multiple Sclerosis
|
||
Active, not recruiting |
NCT04380220 -
Coagulation/Complement Activation and Cerebral Hypoperfusion in Relapsing-remitting Multiple Sclerosis
|
||
Completed |
NCT02835677 -
Integrating Caregiver Support Into MS Care
|
N/A | |
Completed |
NCT03686826 -
Feasibility and Reliability of Multimodal Evoked Potentials
|
||
Recruiting |
NCT05964829 -
Impact of the Cionic Neural Sleeve on Mobility in Multiple Sclerosis
|
N/A | |
Withdrawn |
NCT06021561 -
Orofacial Pain in Multiple Sclerosis
|
||
Completed |
NCT03653585 -
Cortical Lesions in Patients With Multiple Sclerosis
|
||
Recruiting |
NCT04798651 -
Pathogenicity of B and CD4 T Cell Subsets in Multiple Sclerosis
|
N/A | |
Active, not recruiting |
NCT05054140 -
Study to Evaluate Efficacy, Safety, and Tolerability of IMU-838 in Patients With Progressive Multiple Sclerosis
|
Phase 2 | |
Completed |
NCT05447143 -
Effect of Home Exercise Program on Various Parameters in Patients With Multiple Sclerosis
|
N/A | |
Recruiting |
NCT06195644 -
Effect of Galvanic Vestibular Stimulation on Cortical Excitability and Hand Dexterity in Multiple Sclerosis Patients
|
Phase 1 | |
Completed |
NCT04147052 -
iSLEEPms: An Internet-Delivered Intervention for Sleep Disturbance in Multiple Sclerosis
|
N/A | |
Completed |
NCT03594357 -
Cognitive Functions in Patients With Multiple Sclerosis
|
||
Completed |
NCT03591809 -
Combined Exercise Training in Patients With Multiple Sclerosis
|
N/A | |
Completed |
NCT03269175 -
BENEFIT 15 Long-term Follow-up Study of the BENEFIT and BENEFIT Follow-up Studies
|
Phase 4 |