Multiple Sclerosis Clinical Trial
Official title:
Intensity Depended Impact of a Single Exercise Bout on Cognitive Functions in Persons With Multiple Sclerosis - a Pilot Study
Multiple Sclerosis (MS) is a chronic autoimmune disease where lymphocytes inflict damage to
the axons and myelin sheaths of the central nervous system. Persons with multiple sclerosis
(pwMS) were long advised to avoid physical activity but the benefits of exercise to improve
cardiovascular and cognitive functions in pwMS have become important aspects of standardized
rehabilitation programs. Recent findings show that the achieved adaptations through exercise
are associated with the intensity dependent lactate increases during exercise. This
dose-response relationship between the mode and the exercise intensity implicates the
relevance of the exercise protocol as higher exercise intensities seem to facilitate greater
benefits, also in pwMS.
This pilot study evaluates the influences of acute bout of moderate physical exercise
(cycling) and relaxation on cognitive functions at three time points.
Primary outcomes are the differences (at timepoint t2) of cognitive functions assessed via
the Symbol Digit Modalities Test (SDMT) and the Brief Visuospatial Memory Test Revised
(BVMT-R) T1-3 of the BICAMS battery.
Results should into a randomised controlled Trial that investigates the specific influences
of a three-week training intervention on Brain-derived neurotrophic factors (BDNF), Insulin
Growth Factor-1 (IGF-1) and Vascular Endothelial Growth Factor (VEGF) as central
neurobiological parameters of neuroplasticity, cardiorespiratory Fitness and cognitive
functions.
Status | Unknown status |
Enrollment | 20 |
Est. completion date | May 2015 |
Est. primary completion date | May 2015 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 19 Years to 80 Years |
Eligibility |
Inclusion Criteria: - Expanded Disability status scale (EDSS) score of 1.5 - 6.0 Exclusion Criteria: - Persisted infections, acute psychotic disorders, cardiovascular and pulmonal diseases, neuropsychological disorders that serverly impact the assessment or were psychotropic medication within the last six week. |
Country | Name | City | State |
---|---|---|---|
Switzerland | Kliniken-Valens | Valens | Sankt Gallen |
Lead Sponsor | Collaborator |
---|---|
Jens Bansi |
Switzerland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Brief International Cognitive Assessment of Multiple Sclerosis (BICAMS) | Cognitive assessment battery consisting of Symbol Digit modality test (SDMT) and the Brief Visuospatial Memory Test Revised (BVMT-R) T1-3. | 3 months | |
Secondary | Cardiorespiratory parameters | Resting and maximum heart rate achieved in cardiopulmonary exercise test | 3 months | |
Secondary | Lactate | Lactate concentrations under rest, at the thresholds (lactate and respiratory compensation Point) | 3 months |
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