Multiple Sclerosis Clinical Trial
Official title:
Integrative Group-based Cognitive Rehabilitation Efficacy in Multiple Sclerosis: a Randomized Clinical Trial
Verified date | November 2017 |
Source | University of Deusto |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The study design was a parallel-group randomized trial with equal randomization. Recruitment
and enrollment were conducted between January 2013 and March 2013. At base-line, cognitive
data was collected. Afterwards, the participants were randomly allocated to either the
REHACOP group or the Control group. During 3 months the intervention with REHACOP program
took place and at follow-up patients were again re-evaluated to evaluate the change in
cognitive measure. Post-treatment assessment (finished by July 2013) was performed within the
first week after completing the intervention. Optional enrollment in pre-post neuroimaging
will also allow us to look at changes in the brain.
Objective: To examine the efficacy of an integrative cognitive training program (REHACOP) to
improve cognition of patients with Multiple Sclerosis (MS).
Status | Completed |
Enrollment | 32 |
Est. completion date | July 2013 |
Est. primary completion date | July 2013 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 20 Years to 60 Years |
Eligibility |
Inclusion Criteria: i) age 20-60 years ii) either male or female iii) patients with relapsing-remitting, secondary progressive or primary progressive MS Exclusion criteria: i) presence of dementia ii) have suffered an exacerbation during the previous month to the cognitive assessment iii) being treated with corticosteroids iv) presence of other neurological disorder v) history of stroke or traumatic brain injury resulting in more than 30 minutes loss of consciousness vi) presence of psychiatric disorders |
Country | Name | City | State |
---|---|---|---|
Spain | University of Deusto | Bilbao | Biskai |
Lead Sponsor | Collaborator |
---|---|
University of Deusto |
Spain,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in attention after receiving cognitive rehabilitation treatment | Attention was measured using the Brief Test of Attention (BTA). | 3 months | |
Primary | Change in working memory after receiving cognitive remediation treatment | Working memory was measured using the Backward Digits (BD) subtest of the Wechsler Adult Intelligence Scale III. | 3 months | |
Primary | Change in processing speed after receiving cognitive remediation treatment | Processing speed was measured using a composite score which included the Symbol Digit Modalities Test (SDMT), the three and six letter version of the Salthouse Perceptual Comparison Test (PCT) and the Trail Making Test A (TMTA). | 3 months | |
Primary | Change in verbal memory after receiving cognitive remediation treatment | Verbal memory was measured using The Hopkins Verbal Learning Test - Revised (HVLT-R). | 3 months | |
Primary | Change in verbal fluency after receiving cognitive remediation treatment | Verbal fluency was measured using the Calibrated Ideational Fluency Assessment (CIFA). | 3 months | |
Primary | Change in executive functioning after receiving cognitive remediation treatment. | Executive functioning was measured with the Stroop Color-Word Test. | 3 months |
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