The Effect of Aerobic Exercise on Cognitive Function and Sleep Quality in Individuals With Multiple Sclerosis

Multiple Sclerosis Clinical Trial

Official title:

The Effect of Aerobic Exercise on Cognitive Function and Sleep Quality in Individuals With Multiple Sclerosis

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01783665
• Other study ID #: 13332
• Status: Completed
• Phase: N/A
• Start date: August 2012
• Est. completion date: December 2015

Study information

• Verified date: February 2016
• Source: University of Kansas Medical Center
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

In addition to the typical motor and sensory impairments, individuals with multiple sclerosis (MS) often experience cognitive dysfunction and sleep disturbances. Cognitive impairment occurs in 40 % - 70% of patients with MS. In addition, sleep problems in individuals with MS are very common, and approximately 50% of patients with MS have a diagnosable sleep disorder. The research believes that aerobic exercise improve cognitive function and improve sleep quality.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 28
• Est. completion date: December 2015
• Est. primary completion date: December 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 21 Years to 80 Years

Eligibility

Inclusion Criteria:

• diagnosis of relapsing remitting or secondary progressive MS

• score 3-7 on the EDSS

• score < 55 on the Symbol Digit Modalities Test

• score > 5 on the Pittsburgh Sleep Quality Index

Exclusion Criteria:

• history of alcohol/drug abuse or nervous system disorder other than MS

• severe physical, neurological, or sensory impairments that would interfere significantly with testing

• developmental history of learning disability or attention-deficit/hyperactivity disorder

• relapse and/or corticosteroid use within four weeks of assessment

• unable to give consent

• uncorrected vision loss that would interfere significantly with testing

• score less than 24 on MMSE

• Acute ischemic cardiovascular event or coronary artery bypass surgery less than 3 months ago

• Either unable to physically perform the exercise test using the recumbent stepper or demonstrate absolute indications for terminating exercise that follows the American College of Sports Medicine's (ACSM) guidelines

• Uncontrolled blood pressure with medication (BP > 190/110mmHg)

Related Conditions & MeSH terms

• Multiple Sclerosis
• Sclerosis

Intervention

Other:
• aerobic exercise

• home exercise program

Locations

Country	Name	City	State
United States	University of Kansas Medical Center	Kansas City	Kansas

Sponsors (1)

Lead Sponsor	Collaborator
Catherine Siengsukon, PT, PhD

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in Cognitive Function		Baseline to Month 3
Secondary	Change in Sleep Quality		Baseline to Month 3