Multiple Sclerosis Clinical Trial
Official title:
Respiratory Function and Walking Capacity in Multiple Sclerosis
Verified date | January 2017 |
Source | Region Örebro County |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Multiple sclerosis (MS) is a chronic progressive neurological disease. Respiratory
dysfunction due to weakness in the respiratory musculature has been described in MS. This
leads to increased morbidity and mortality in late stages of the disease. It is possible
that respiratory dysfunction influence physical fitness in earlier stages as well. Walking
disability and fatigue causes significant impact on health in patients with MS, even in
earlier stages.
The hypothesis is that there is a relationship between respiratory function, walking
capacity and fatigue and that daily deep breathing exercise during two months will improve
respiratory function, walking capacity and fatigue.
Status | Completed |
Enrollment | 50 |
Est. completion date | December 2014 |
Est. primary completion date | December 2014 |
Accepts healthy volunteers | No |
Gender | All |
Age group | N/A and older |
Eligibility |
Inclusion Criteria: - Inhabitant in Orebro county, Sweden, that are diagnosed with MS according to the revised McDonald criteria and registered in the Swedish MS-registry with EDSS (Expanded disability status scale) score in the interval = 3.0 - = 7.0. - Participants must understand verbal and written information and must be relapse free = 3 months prior to inclusion. Exclusion Criteria: - Patients with diseases that may have influence on walking ability and respiratory function (other than MS). Such conditions include heart and lung diseases, orthopedic disorders, patients recently subjected to surgery, and non-MS related neurological dysfunction. |
Country | Name | City | State |
---|---|---|---|
n/a |
Lead Sponsor | Collaborator |
---|---|
Region Örebro County | Örebro County Council |
Nilsagård Y, Westerdahl E, Wittrin A, Gunnarsson M. Walking Distance as a Predictor of Falls in People With Multiple Sclerosis. Physiother Res Int. 2016 Jun;21(2):102-8. doi: 10.1002/pri.1625. — View Citation
Westerdahl E, Wittrin A, Kånåhols M, Gunnarsson M, Nilsagård Y. Deep breathing exercises with positive expiratory pressure in patients with multiple sclerosis - a randomized controlled trial. Clin Respir J. 2016 Nov;10(6):698-706. doi: 10.1111/crj.12272. — View Citation
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Respiratory muscle strength | Maximum expiratory pressure | Two months |
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