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Keratinocyte Growth Factor to Prevent Autoimmunity After Alemtuzumab Treatment of Multiple Sclerosis — CAM-THY  

Multiple Sclerosis Clinical Trial

Official title:
Keratinocyte Growth Factor - Promoting Thymic Reconstitution and Preventing Autoimmunity After Alemtuzumab (Campath-1H) Treatment of Multiple Sclerosis

Clinical Trial Summary

The purpose of this study is to test a novel strategy to prevent the clinical problem of secondary autoimmunity following alemtuzumab treatment of multiple sclerosis.

The hypothesis is that autoimmunity after alemtuzumab can be prevented by giving a drug that promotes thymic T cell regeneration (Palifermin, Kepivance®).

Clinical Trial Description

This is a single-centre, double-blinded, randomised controlled trial of palifermin (Kepivance) vs. placebo in the prevention of autoimmunity following alemtuzumab treatment of multiple sclerosis.

The dose of palifermin (kepivance)used in this trial will be informed by a dose-escalation study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT01712945
Study type Interventional
Source Cambridge University Hospitals NHS Foundation Trust
Contact
Status Terminated
Phase Phase 1/Phase 2
Start date June 2012
Completion date October 2017
View Details
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